Mag-VLA: Vision-Language-Action Model for Bimanual Magnetically Actuated Microrobot Manipulation

Magnetically actuated microrobots have been used as wireless, non-contact manipulation tools at microscales, making them promising for minimally invasive applications. However, their control remains challenging due to indirect actuation, limited sensing, and nonlinear magnetic interactions. In this work, we propose Mag-VLA, a vision-language-action (VLA) model for dexterous magnetic microrobot manipulation using two robotic arms with mounted magnets for dynamic magnetic-field construction. Bimanual coordination enables capabilities such as microrobot reorientation that are difficult or infeasible with a single arm, but it also introduces coupled control challenges, as the policy must generate coordinated trajectories for both actuators within a shared workspace. Our framework adapts a Qwen2.5-VL-7B backbone using Low-Rank Adaptation (LoRA) to process visual observations and language instructions for action prediction. To capture task progression, we introduce a motion-aware phase classifier and a phase-conditioned Action Chunking Transformer (ACT) decoder for temporally coherent multi-step control. We further construct a teleoperated magnetic microrobot manipulation dataset covering three task configurations. Ablation studies show that the ACT-based decoder substantially outperforms alternative generative action heads. In real-robot experiments, Mag-VLA achieves a 90% approach success rate across all tasks and transport success rates of 80%, 70%, and 50% as task difficulty increases. These results demonstrate that hierarchical VLA modeling provides a promising framework for magnetic microrobot manipulation.

Dual-Control Frequency-Aware Diffusion Model for Depth-Dependent Optical Microrobot Microscopy Image Generation

Optical microrobots actuated by optical tweezers (OT) are important for cell manipulation and microscale assembly, but their autonomous operation depends on accurate 3D perception. Developing such perception systems is challenging because large-scale, high-quality microscopy datasets are scarce, owing to complex fabrication processes and labor-intensive annotation. Although generative AI offers a promising route for data augmentation, existing generative adversarial network (GAN)-based methods struggle to reproduce key optical characteristics, particularly depth-dependent diffraction and defocus effects. To address this limitation, we propose Du-FreqNet, a dual-control, frequency-aware diffusion model for physically consistent microscopy image synthesis. The framework features two independent ControlNet branches to encode microrobot 3D point clouds and depth-specific mesh layers, respectively. We introduce an adaptive frequency-domain loss that dynamically reweights high- and low-frequency components based on the distance to the focal plane. By leveraging differentiable FFT-based supervision, Du-FreqNet captures physically meaningful frequency distributions often missed by pixel-space methods. Trained on a limited dataset (e.g., 80 images per pose), our model achieves controllable, depth-dependent image synthesis, improving SSIM by 20.7% over baselines. Extensive experiments demonstrate that Du-FreqNet generalizes effectively to unseen poses and significantly enhances downstream tasks, including 3D pose and depth estimation, thereby facilitating robust closed-loop control in microrobotic systems.

Micro-Dexterity in Biological Micromanipulation: Embodiment, Perception, and Control

Microscale manipulation has advanced substantially in controlled locomotion and targeted transport, yet many biomedical applications require precise and adaptive interaction with biological micro-objects. At these scales, manipulation is realized through three main classes of platforms: embodied microrobots that physically interact as mobile agents, field-mediated systems that generate contactless trapping or manipulation forces, and externally actuated end-effectors that interact through remotely driven physical tools. Unlike macroscale manipulators, these systems function in fluidic, confined, and surface-dominated environments characterized by negligible inertia, dominant interfacial forces, and soft, heterogeneous, and fragile targets. Consequently, classical assumptions of dexterous manipulation, including rigid-body contact, stable grasping, and rich proprioceptive feedback, become difficult to maintain. This review introduces micro-dexterity as a framework for analyzing biological micromanipulation through the coupled roles of embodiment, perception, and control. We examine how classical manipulation primitives, including pushing, reorientation, grasping, and cooperative manipulation, are reformulated at the microscale; compare the architectures that enable them, from contact-based micromanipulators to contactless field-mediated systems and cooperative multi-agent platforms; and review the perception and control strategies required for task execution. We identify the current dexterity gap between laboratory demonstrations and clinically relevant biological manipulation, and outline key challenges for future translation.