Enhancing Signal Proportion Estimation Through Leveraging Arbitrary Covariance Structures

Accurately estimating the proportion of true signals among a large number of variables is crucial for enhancing the precision and reliability of scientific research. Traditional signal proportion estimators often assume independence among variables and specific signal sparsity conditions, limiting their applicability in real-world scenarios where such assumptions may not hold. This paper introduces a novel signal proportion estimator that leverages arbitrary covariance dependence information among variables, thereby improving performance across a wide range of sparsity levels and dependence structures. Building on previous work that provides lower confidence bounds for signal proportions, we extend this approach by incorporating the principal factor approximation procedure to account for variable dependence. Our theoretical insights offer a deeper understanding of how signal sparsity, signal intensity, and covariance dependence interact. By comparing the conditions for estimation consistency before and after dependence adjustment, we highlight the advantages of integrating dependence information across different contexts. This theoretical foundation not only validates the effectiveness of the new estimator but also guides its practical application, ensuring reliable use in diverse scenarios. Through extensive simulations, we demonstrate that our method outperforms state-of-the-art estimators in both estimation accuracy and the detection of weaker signals that might otherwise go undetected.

Learning Gaussian Graphical Models Using Discriminated Hub Graphical Lasso

We develop a new method called Discriminated Hub Graphical Lasso (DHGL) based on Hub Graphical Lasso (HGL) by providing prior information of hubs. We apply this new method in two situations: with known hubs and without known hubs. Then we compare DHGL with HGL using several measures of performance. When some hubs are known, we can always estimate the precision matrix better via DHGL than HGL. When no hubs are known, we use Graphical Lasso (GL) to provide information of hubs and find that the performance of DHGL will always be better than HGL if correct prior information is given and will seldom degenerate when the prior information is wrong.