Validation of a CT-brain analysis tool for measuring global cortical atrophy in older patient cohorts

Quantification of brain atrophy currently requires visual rating scales which are time consuming and automated brain image analysis is warranted. We validated our automated deep learning (DL) tool measuring the Global Cerebral Atrophy (GCA) score against trained human raters, and associations with age and cognitive impairment, in representative older (>65 years) patients. CT-brain scans were obtained from patients in acute medicine (ORCHARD-EPR), acute stroke (OCS studies) and a legacy sample. Scans were divided in a 60/20/20 ratio for training, optimisation and testing. CT-images were assessed by two trained raters (rater-1=864 scans, rater-2=20 scans). Agreement between DL tool-predicted GCA scores (range 0-39) and the visual ratings was evaluated using mean absolute error (MAE) and Cohen's weighted kappa. Among 864 scans (ORCHARD-EPR=578, OCS=200, legacy scans=86), MAE between the DL tool and rater-1 GCA scores was 3.2 overall, 3.1 for ORCHARD-EPR, 3.3 for OCS and 2.6 for the legacy scans and half had DL-predicted GCA error between -2 and 2. Inter-rater agreement was Kappa=0.45 between the DL-tool and rater-1, and 0.41 between the tool and rater- 2 whereas it was lower at 0.28 for rater-1 and rater-2. There was no difference in GCA scores from the DL-tool and the two raters (one-way ANOVA, p=0.35) or in mean GCA scores between the DL-tool and rater-1 (paired t-test, t=-0.43, p=0.66), the tool and rater-2 (t=1.35, p=0.18) or between rater-1 and rater-2 (t=0.99, p=0.32). DL-tool GCA scores correlated with age and cognitive scores (both p<0.001). Our DL CT-brain analysis tool measured GCA score accurately and without user input in real-world scans acquired from older patients. Our tool will enable extraction of standardised quantitative measures of atrophy at scale for use in health data research and will act as proof-of-concept towards a point-of-care clinically approved tool.

Let CONAN tell you a story: Procedural quest generation

This work proposes an engine for the Creation Of Novel Adventure Narrative (CONAN), which is a procedural quest generator. It uses a planning approach to story generation. The engine is tested on its ability to create quests, which are sets of actions that must be performed in order to achieve a certain goal, usually for a reward. The engine takes in a world description represented as a set of facts, including characters, locations, and items, and generates quests according to the state of the world and the preferences of the characters. We evaluate quests through the classification of the motivations behind the quests, based on the sequences of actions required to complete the quests. We also compare different world descriptions and analyze the difference in motivations for the quests produced by the engine. Compared against human structural quest analysis, the current engine was found to be able to replicate the quest structures found in commercial video game quests.

Image Quality Assessment Techniques Show Improved Training and Evaluation of Autoencoder Generative Adversarial Networks

We propose a training and evaluation approach for autoencoder Generative Adversarial Networks (GANs), specifically the Boundary Equilibrium Generative Adversarial Network (BEGAN), based on methods from the image quality assessment literature. Our approach explores a multidimensional evaluation criterion that utilizes three distance functions: an $l_1$ score, the Gradient Magnitude Similarity Mean (GMSM) score, and a chrominance score. We show that each of the different distance functions captures a slightly different set of properties in image space and, consequently, requires its own evaluation criterion to properly assess whether the relevant property has been adequately learned. We show that models using the new distance functions are able to produce better images than the original BEGAN model in predicted ways.