A Survey on Conversational Search and Applications in Biomedicine

This paper aims to provide a radical rundown on Conversation Search (ConvSearch), an approach to enhance the information retrieval method where users engage in a dialogue for the information-seeking tasks. In this survey, we predominantly focused on the human interactive characteristics of the ConvSearch systems, highlighting the operations of the action modules, likely the Retrieval system, Question-Answering, and Recommender system. We labeled various ConvSearch research problems in knowledge bases, natural language processing, and dialogue management systems along with the action modules. We further categorized the framework to ConvSearch and the application is directed toward biomedical and healthcare fields for the utilization of clinical social technology. Finally, we conclude by talking through the challenges and issues of ConvSearch, particularly in Bio-Medicine. Our main aim is to provide an integrated and unified vision of the ConvSearch components from different fields, which benefit the information-seeking process in healthcare systems.

Improved Biomedical Word Embeddings in the Transformer Era

Biomedical word embeddings are usually pre-trained on free text corpora with neural methods that capture local and global distributional properties. They are leveraged in downstream tasks using various neural architectures that are designed to optimize task-specific objectives that might further tune such embeddings. Since 2018, however, there is a marked shift from these static embeddings to contextual embeddings motivated by language models (e.g., ELMo, transformers such as BERT, and ULMFiT). These dynamic embeddings have the added benefit of being able to distinguish homonyms and acronyms given their context. However, static embeddings are still relevant in low resource settings (e.g., smart devices, IoT elements) and to study lexical semantics from a computational linguistics perspective. In this paper, we jointly learn word and concept embeddings by first using the skip-gram method and further fine-tuning them with correlational information manifesting in co-occurring Medical Subject Heading (MeSH) concepts in biomedical citations. This fine-tuning is accomplished with the BERT transformer architecture in the two-sentence input mode with a classification objective that captures MeSH pair co-occurrence. In essence, we repurpose a transformer architecture (typically used to generate dynamic embeddings) to improve static embeddings using concept correlations. We conduct evaluations of these tuned static embeddings using multiple datasets for word relatedness developed by previous efforts. Without selectively culling concepts and terms (as was pursued by previous efforts), we believe we offer the most exhaustive evaluation of static embeddings to date with clear performance improvements across the board. We provide our code and embeddings for public use for downstream applications and research endeavors: https://github.com/bionlproc/BERT-CRel-Embeddings

Literature Retrieval for Precision Medicine with Neural Matching and Faceted Summarization

Information retrieval (IR) for precision medicine (PM) often involves looking for multiple pieces of evidence that characterize a patient case. This typically includes at least the name of a condition and a genetic variation that applies to the patient. Other factors such as demographic attributes, comorbidities, and social determinants may also be pertinent. As such, the retrieval problem is often formulated as ad hoc search but with multiple facets (e.g., disease, mutation) that may need to be incorporated. In this paper, we present a document reranking approach that combines neural query-document matching and text summarization toward such retrieval scenarios. Our architecture builds on the basic BERT model with three specific components for reranking: (a). document-query matching (b). keyword extraction and (c). facet-conditioned abstractive summarization. The outcomes of (b) and (c) are used to essentially transform a candidate document into a concise summary that can be compared with the query at hand to compute a relevance score. Component (a) directly generates a matching score of a candidate document for a query. The full architecture benefits from the complementary potential of document-query matching and the novel document transformation approach based on summarization along PM facets. Evaluations using NIST's TREC-PM track datasets (2017--2019) show that our model achieves state-of-the-art performance. To foster reproducibility, our code is made available here: https://github.com/bionlproc/text-summ-for-doc-retrieval.