Only-Train-Once MR Fingerprinting for Magnetization Transfer Contrast Quantification

Magnetization transfer contrast magnetic resonance fingerprinting (MTC-MRF) is a novel quantitative imaging technique that simultaneously measures several tissue parameters of semisolid macromolecule and free bulk water. In this study, we propose an Only-Train-Once MR fingerprinting (OTOM) framework that estimates the free bulk water and MTC tissue parameters from MR fingerprints regardless of MRF schedule, thereby avoiding time-consuming process such as generation of training dataset and network training according to each MRF schedule. A recurrent neural network is designed to cope with two types of variants of MRF schedules: 1) various lengths and 2) various patterns. Experiments on digital phantoms and in vivo data demonstrate that our approach can achieve accurate quantification for the water and MTC parameters with multiple MRF schedules. Moreover, the proposed method is in excellent agreement with the conventional deep learning and fitting methods. The flexible OTOM framework could be an efficient tissue quantification tool for various MRF protocols.

Synthesis of Brain Tumor MR Images for Learning Data Augmentation

Medical image analysis using deep neural networks has been actively studied. Deep neural networks are trained by learning data. For accurate training of deep neural networks, the learning data should be sufficient, of good quality, and should have a generalized property. However, in medical images, it is difficult to acquire sufficient patient data because of the difficulty of patient recruitment, the burden of annotation of lesions by experts, and the invasion of patients' privacy. In comparison, the medical images of healthy volunteers can be easily acquired. Using healthy brain images, the proposed method synthesizes multi-contrast magnetic resonance images of brain tumors. Because tumors have complex features, the proposed method simplifies them into concentric circles that are easily controllable. Then it converts the concentric circles into various realistic shapes of tumors through deep neural networks. Because numerous healthy brain images are easily available, our method can synthesize a huge number of the brain tumor images with various concentric circles. We performed qualitative and quantitative analysis to assess the usefulness of augmented data from the proposed method. Intuitive and interesting experimental results are available online at https://github.com/KSH0660/BrainTumor

Attention Guided Metal Artifact Correction in MRI using Deep Neural Networks

An attention guided scheme for metal artifact correction in MRI using deep neural network is proposed in this paper. The inputs of the networks are two distorted images obtained with dual-polarity readout gradients. With MR image generation module and the additional data consistency loss to the previous work [1], the network is trained to estimate the frequency-shift map, off-resonance map, and attention map. The attention map helps to produce better distortion-corrected images by weighting on more relevant distortion-corrected images where two distortion-corrected images are produced with half of the frequency-shift maps. In this paper, we observed that in a real MRI environment, two distorted images obtained with opposite polarities of readout gradient showed artifacts in a different region. Therefore, we proved that using the attention map was important in that it reduced the residual ripple and pile-up artifacts near metallic implants.