Patient-Level Diagnosis of Acute Myeloid Leukemia via Deep Learning Analysis of Bone Marrow Smear

Bone marrow smear review remains important for acute myeloid leukemia (AML) assessment, but manual single-cell interpretation is labor-intensive and patient-level diagnosis requires aggregation of many cellular observations. We present a cell-to-patient deep learning pipeline for AML-assisted diagnosis from bone marrow smear images. The study included 258 patients from six anonymized centers, including a main cohort of 169 patients from Centers 1-3 and an external validation cohort of 89 patients from Centers 4-6. A 16-category cell annotation vocabulary was used to describe the global cellular composition, including granulocytic, monocytic, erythroid, lymphoid, eosinophilic, and other cells. Rather than identifying strict AML blasts or leukemic blasts, the model targets an expert-defined composite category termed Composite Blast-like Cells (CBLC), comprising N, N1, M, M1, R, R1, J, and J1 according to the project-wide morphological standard. A fixed YOLO-based segmentation module detected cells, predicted contours were matched to expert polygon annotations by contour IoU, and standardized single-cell crops were generated. An EfficientNet-B0 classifier was trained through a two-stage GT-to-YOLO and YOLO-to-YOLO strategy with class-imbalance correction, center-border regularization, and morphology-assisted supervision. Cell-level predictions were aggregated into patient-level CBLC ratios for AML-oriented diagnostic support. The pipeline achieved stable internal validation and maintained external generalization, with ensemble weighted F1-scores of 0.9076, 0.8696, and 0.9124 on Centers 4, 5, and 6, respectively.

CADIC: Continual Anomaly Detection Based on Incremental Coreset

The primary objective of Continual Anomaly Detection (CAD) is to learn the normal patterns of new tasks under dynamic data distribution assumptions while mitigating catastrophic forgetting. Existing embedding-based CAD approaches continuously update a memory bank with new embeddings to adapt to sequential tasks. However, these methods require constructing class-specific sub-memory banks for each task, which restricts their flexibility and scalability. To address this limitation, we propose a novel CAD framework where all tasks share a unified memory bank. During training, the method incrementally updates embeddings within a fixed-size coreset, enabling continuous knowledge acquisition from sequential tasks without task-specific memory fragmentation. In the inference phase, anomaly scores are computed via a nearest-neighbor matching mechanism, achieving state-of-the-art detection accuracy. We validate the method through comprehensive experiments on MVTec AD and Visa datasets. Results show that our approach outperforms existing baselines, achieving average image-level AUROC scores of 0.972 (MVTec AD) and 0.891 (Visa). Notably, on a real-world electronic paper dataset, it demonstrates 100% accuracy in anomaly sample detection, confirming its robustness in practical scenarios. The implementation will be open-sourced on GitHub.