Controllable Latent Space Augmentation for Digital Pathology

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level tasks, training robust models requires large and diverse datasets. Even though image augmentation techniques could be utilized to increase data variability and reduce overfitting, implementing them effectively is not a trivial task. Traditional patch-level augmentation is prohibitively expensive due to the large number of patches extracted from each WSI, and existing feature-level augmentation methods lack control over transformation semantics. We introduce HistAug, a fast and efficient generative model for controllable augmentations in the latent space for digital pathology. By conditioning on explicit patch-level transformations (e.g., hue, erosion), HistAug generates realistic augmented embeddings while preserving initial semantic information. Our method allows the processing of a large number of patches in a single forward pass efficiently, while at the same time consistently improving MIL model performance. Experiments across multiple slide-level tasks and diverse organs show that HistAug outperforms existing methods, particularly in low-data regimes. Ablation studies confirm the benefits of learned transformations over noise-based perturbations and highlight the importance of uniform WSI-wise augmentation. Code is available at https://github.com/MICS-Lab/HistAug.

Dictionary Learning for Deblurring and Digital Zoom

This paper proposes a novel approach to image deblurring and digital zooming using sparse local models of image appearance. These models, where small image patches are represented as linear combinations of a few elements drawn from some large set (dictionary) of candidates, have proven well adapted to several image restoration tasks. A key to their success has been to learn dictionaries adapted to the reconstruction of small image patches. In contrast, recent works have proposed instead to learn dictionaries which are not only adapted to data reconstruction, but also tuned for a specific task. We introduce here such an approach to deblurring and digital zoom, using pairs of blurry/sharp (or low-/high-resolution) images for training, as well as an effective stochastic gradient algorithm for solving the corresponding optimization task. Although this learning problem is not convex, once the dictionaries have been learned, the sharp/high-resolution image can be recovered via convex optimization at test time. Experiments with synthetic and real data demonstrate the effectiveness of the proposed approach, leading to state-of-the-art performance for non-blind image deblurring and digital zoom.