CytoBERT: A Foundation Model for Cytometry Data

Cytometry measures the complex characteristics of single cells (e.g., counts and protein expression of immune cells) and is widely used across immunological research and clinical settings. However, cytometry data is highly heterogeneous and unstandardized due to experimental protocols and the choice of measured features. While machine learning methods hold the potential to gain deeper insights into cell biology, these challenges make them difficult to apply and transfer across studies. Recent advances in foundation models can alleviate these issues, but corresponding approaches are still scarce in this field. To address this, we provide CytoBERT, a publicly available, open-source, open-weight foundation model for single-cell cytometry data with variable marker panels. CytoBERT is pretrained in a self-supervised manner on a large-scale cytometry corpus (15 human datasets with heterogeneous marker panels and more than 50 million cells) curated through marker standardization, enabling it to learn transferable inter-marker relationships within cells. Fine-tuning CytoBERT for sample-level classification demonstrates that transfer learning across heterogeneous cytometry datasets is feasible, providing a starting point for scalable, generalizable cytometry analysis. Code is available at GitHub.

Wavelet-Packet Powered Deepfake Image Detection

As neural networks become more able to generate realistic artificial images, they have the potential to improve movies, music, video games and make the internet an even more creative and inspiring place. Yet, at the same time, the latest technology potentially enables new digital ways to lie. In response, the need for a diverse and reliable toolbox arises to identify artificial images and other content. Previous work primarily relies on pixel-space CNN or the Fourier transform. To the best of our knowledge, wavelet-based gan analysis and detection methods have been absent thus far. This paper aims to fill this gap and describes a wavelet-based approach to gan-generated image analysis and detection. We evaluate our method on FFHQ, CelebA, and LSUN source identification problems and find improved or competitive performance.