A Sparse-Attention Deep Learning Model Integrating Heterogeneous Multimodal Features for Parkinson's Disease Severity Profiling

Characterising the heterogeneous presentation of Parkinson's disease (PD) requires integrating biological and clinical markers within a unified predictive framework. While multimodal data provide complementary information, many existing computational models struggle with interpretability, class imbalance, or effective fusion of high-dimensional imaging and tabular clinical features. To address these limitations, we propose the Class-Weighted Sparse-Attention Fusion Network (SAFN), an interpretable deep learning framework for robust multimodal profiling. SAFN integrates MRI cortical thickness, MRI volumetric measures, clinical assessments, and demographic variables using modality-specific encoders and a symmetric cross-attention mechanism that captures nonlinear interactions between imaging and clinical representations. A sparsity-constrained attention-gating fusion layer dynamically prioritises informative modalities, while a class-balanced focal loss (beta = 0.999, gamma = 1.5) mitigates dataset imbalance without synthetic oversampling. Evaluated on 703 participants (570 PD, 133 healthy controls) from the Parkinson's Progression Markers Initiative using subject-wise five-fold cross-validation, SAFN achieves an accuracy of 0.98 plus or minus 0.02 and a PR-AUC of 1.00 plus or minus 0.00, outperforming established machine learning and deep learning baselines. Interpretability analysis shows a clinically coherent decision process, with approximately 60 percent of predictive weight assigned to clinical assessments, consistent with Movement Disorder Society diagnostic principles. SAFN provides a reproducible and transparent multimodal modelling paradigm for computational profiling of neurodegenerative disease.

ReflectGAN: Modeling Vegetation Effects for Soil Carbon Estimation from Satellite Imagery

Soil organic carbon (SOC) is a critical indicator of soil health, but its accurate estimation from satellite imagery is hindered in vegetated regions due to spectral contamination from plant cover, which obscures soil reflectance and reduces model reliability. This study proposes the Reflectance Transformation Generative Adversarial Network (ReflectGAN), a novel paired GAN-based framework designed to reconstruct accurate bare soil reflectance from vegetated soil satellite observations. By learning the spectral transformation between vegetated and bare soil reflectance, ReflectGAN facilitates more precise SOC estimation under mixed land cover conditions. Using the LUCAS 2018 dataset and corresponding Landsat 8 imagery, we trained multiple learning-based models on both original and ReflectGAN-reconstructed reflectance inputs. Models trained on ReflectGAN outputs consistently outperformed those using existing vegetation correction methods. For example, the best-performing model (RF) achieved an $R^2$ of 0.54, RMSE of 3.95, and RPD of 2.07 when applied to the ReflectGAN-generated signals, representing a 35\% increase in $R^2$, a 43\% reduction in RMSE, and a 43\% improvement in RPD compared to the best existing method (PMM-SU). The performance of the models with ReflectGAN is also better compared to their counterparts when applied to another dataset, i.e., Sentinel-2 imagery. These findings demonstrate the potential of ReflectGAN to improve SOC estimation accuracy in vegetated landscapes, supporting more reliable soil monitoring.