Application of Quantum Tensor Networks for Protein Classification

We show that protein sequences can be thought of as sentences in natural language processing and can be parsed using the existing Quantum Natural Language framework into parameterized quantum circuits of reasonable qubits, which can be trained to solve various protein-related machine-learning problems. We classify proteins based on their subcellular locations, a pivotal task in bioinformatics that is key to understanding biological processes and disease mechanisms. Leveraging the quantum-enhanced processing capabilities, we demonstrate that Quantum Tensor Networks (QTN) can effectively handle the complexity and diversity of protein sequences. We present a detailed methodology that adapts QTN architectures to the nuanced requirements of protein data, supported by comprehensive experimental results. We demonstrate two distinct QTNs, inspired by classical recurrent neural networks (RNN) and convolutional neural networks (CNN), to solve the binary classification task mentioned above. Our top-performing quantum model has achieved a 94% accuracy rate, which is comparable to the performance of a classical model that uses the ESM2 protein language model embeddings. It's noteworthy that the ESM2 model is extremely large, containing 8 million parameters in its smallest configuration, whereas our best quantum model requires only around 800 parameters. We demonstrate that these hybrid models exhibit promising performance, showcasing their potential to compete with classical models of similar complexity.

Evaluating Efficacy of Model Stealing Attacks and Defenses on Quantum Neural Networks

Cloud hosting of quantum machine learning (QML) models exposes them to a range of vulnerabilities, the most significant of which is the model stealing attack. In this study, we assess the efficacy of such attacks in the realm of quantum computing. We conducted comprehensive experiments on various datasets with multiple QML model architectures. Our findings revealed that model stealing attacks can produce clone models achieving up to $0.9\times$ and $0.99\times$ clone test accuracy when trained using Top-$1$ and Top-$k$ labels, respectively ($k:$ num\_classes). To defend against these attacks, we leverage the unique properties of current noisy hardware and perturb the victim model outputs and hinder the attacker's training process. In particular, we propose: 1) hardware variation-induced perturbation (HVIP) and 2) hardware and architecture variation-induced perturbation (HAVIP). Although noise and architectural variability can provide up to $\sim16\%$ output obfuscation, our comprehensive analysis revealed that models cloned under noisy conditions tend to be resilient, suffering little to no performance degradation due to such obfuscations. Despite limited success with our defense techniques, this outcome has led to an important discovery: QML models trained on noisy hardwares are naturally resistant to perturbation or obfuscation-based defenses or attacks.

WEPRO: Weight Prediction for Efficient Optimization of Hybrid Quantum-Classical Algorithms

The exponential run time of quantum simulators on classical machines and long queue depths and high costs of real quantum devices present significant challenges in the effective training of Variational Quantum Algorithms (VQAs) like Quantum Neural Networks (QNNs), Variational Quantum Eigensolver (VQE) and Quantum Approximate Optimization Algorithm (QAOA). To address these limitations, we propose a new approach, WEPRO (Weight Prediction), which accelerates the convergence of VQAs by exploiting regular trends in the parameter weights. We introduce two techniques for optimal prediction performance namely, Naive Prediction (NaP) and Adaptive Prediction (AdaP). Through extensive experimentation and training of multiple QNN models on various datasets, we demonstrate that WEPRO offers a speedup of approximately $2.25\times$ compared to standard training methods, while also providing improved accuracy (up to $2.3\%$ higher) and loss (up to $6.1\%$ lower) with low storage and computational overheads. We also evaluate WEPRO's effectiveness in VQE for molecular ground-state energy estimation and in QAOA for graph MaxCut. Our results show that WEPRO leads to speed improvements of up to $3.1\times$ for VQE and $2.91\times$ for QAOA, compared to traditional optimization techniques, while using up to $3.3\times$ less number of shots (i.e., repeated circuit executions) per training iteration.