A Multi-Agent Framework for Interpreting Multivariate Physiological Time Series

Continuous physiological monitoring is central to emergency care, yet deploying trustworthy AI is challenging. While LLMs can translate complex physiological signals into clinical narratives, it is unclear how agentic systems perform relative to zero-shot inference. To address these questions, we present Vivaldi, a role-structured multi-agent system that explains multivariate physiological time series. Due to regulatory constraints that preclude live deployment, we instantiate Vivaldi in a controlled, clinical pilot to a small, highly qualified cohort of emergency medicine experts, whose evaluations reveal a context-dependent picture that contrasts with prevailing assumptions that agentic reasoning uniformly improves performance. Our experiments show that agentic pipelines substantially benefit non-thinking and medically fine-tuned models, improving expert-rated explanation justification and relevance by +6.9 and +9.7 points, respectively. Contrarily, for thinking models, agentic orchestration often degrades explanation quality, including a 14-point drop in relevance, while improving diagnostic precision (ESI F1 +3.6). We also find that explicit tool-based computation is decisive for codifiable clinical metrics, whereas subjective targets, such as pain scores and length of stay, show limited or inconsistent changes. Expert evaluation further indicates that gains in clinical utility depend on visualization conventions, with medically specialized models achieving the most favorable trade-offs between utility and clarity. Together, these findings show that the value of agentic AI lies in the selective externalization of computation and structure rather than in maximal reasoning complexity, and highlight concrete design trade-offs and learned lessons, broadly applicable to explainable AI in safety-critical healthcare settings.

Inverse Language Modeling towards Robust and Grounded LLMs

The current landscape of defensive mechanisms for LLMs is fragmented and underdeveloped, unlike prior work on classifiers. To further promote adversarial robustness in LLMs, we propose Inverse Language Modeling (ILM), a unified framework that simultaneously 1) improves the robustness of LLMs to input perturbations, and, at the same time, 2) enables native grounding by inverting model outputs to identify potentially toxic or unsafe input triggers. ILM transforms LLMs from static generators into analyzable and robust systems, potentially helping RED teaming. ILM can lay the foundation for next-generation LLMs that are not only robust and grounded but also fundamentally more controllable and trustworthy. The code is publicly available at github.com/davegabe/pag-llm.

Seamless Monitoring of Stress Levels Leveraging a Universal Model for Time Sequences

Monitoring the stress level in patients with neurodegenerative diseases can help manage symptoms, improve patient's quality of life, and provide insight into disease progression. In the literature, ECG, actigraphy, speech, voice, and facial analysis have proven effective at detecting patients' emotions. On the other hand, these tools are invasive and do not integrate smoothly into the patient's daily life. HRV has also been proven to effectively indicate stress conditions, especially in combination with other signals. However, when HRV is derived from less invasive devices than the ECG, like smartwatches and bracelets, the quality of measurements significantly degrades. This paper presents a methodology for stress detection from a smartwatch based on a universal model for time series, UniTS, which we fine-tuned for the task. We cast the problem as anomaly detection rather than classification to favor model adaptation to individual patients and allow the clinician to maintain greater control over the system's predictions. We demonstrate that our proposed model considerably surpasses 12 top-performing methods on 3 benchmark datasets. Furthermore, unlike other state-of-the-art systems, UniTS enables seamless monitoring, as it shows comparable performance when using signals from invasive or lightweight devices.