SOFA: Deep Learning Framework for Simulating and Optimizing Atrial Fibrillation Ablation

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia often treated with catheter ablation procedures, but procedural outcomes are highly variable. Evaluating and improving ablation efficacy is challenging due to the complex interaction between patient-specific tissue and procedural factors. This paper asks two questions: Can AF recurrence be predicted by simulating the effects of procedural parameters? How should we ablate to reduce AF recurrence? We propose SOFA (Simulating and Optimizing Atrial Fibrillation Ablation), a novel deep-learning framework that addresses these questions. SOFA first simulates the outcome of an ablation strategy by generating a post-ablation image depicting scar formation, conditioned on a patient's pre-ablation LGE-MRI and the specific procedural parameters used (e.g., ablation locations, duration, temperature, power, and force). During this simulation, it predicts AF recurrence risk. Critically, SOFA then introduces an optimization scheme that refines these procedural parameters to minimize the predicted risk. Our method leverages a multi-modal, multi-view generator that processes 2.5D representations of the atrium. Quantitative evaluations show that SOFA accurately synthesizes post-ablation images and that our optimization scheme leads to a 22.18\% reduction in the model-predicted recurrence risk. To the best of our knowledge, SOFA is the first framework to integrate the simulation of procedural effects, recurrence prediction, and parameter optimization, offering a novel tool for personalizing AF ablation.

FBA-Net: Foreground and Background Aware Contrastive Learning for Semi-Supervised Atrium Segmentation

Medical image segmentation of gadolinium enhancement magnetic resonance imaging (GE MRI) is an important task in clinical applications. However, manual annotation is time-consuming and requires specialized expertise. Semi-supervised segmentation methods that leverage both labeled and unlabeled data have shown promise, with contrastive learning emerging as a particularly effective approach. In this paper, we propose a contrastive learning strategy of foreground and background representations for semi-supervised 3D medical image segmentation (FBA-Net). Specifically, we leverage the contrastive loss to learn representations of both the foreground and background regions in the images. By training the network to distinguish between foreground-background pairs, we aim to learn a representation that can effectively capture the anatomical structures of interest. Experiments on three medical segmentation datasets demonstrate state-of-the-art performance. Notably, our method achieves a Dice score of 91.31% with only 20% labeled data, which is remarkably close to the 91.62% score of the fully supervised method that uses 100% labeled data on the left atrium dataset. Our framework has the potential to advance the field of semi-supervised 3D medical image segmentation and enable more efficient and accurate analysis of medical images with a limited amount of annotated labels.