ADHDeepNet From Raw EEG to Diagnosis: Improving ADHD Diagnosis through Temporal-Spatial Processing, Adaptive Attention Mechanisms, and Explainability in Raw EEG Signals

Attention Deficit Hyperactivity Disorder (ADHD) is a common brain disorder in children that can persist into adulthood, affecting social, academic, and career life. Early diagnosis is crucial for managing these impacts on patients and the healthcare system but is often labor-intensive and time-consuming. This paper presents a novel method to improve ADHD diagnosis precision and timeliness by leveraging Deep Learning (DL) approaches and electroencephalogram (EEG) signals. We introduce ADHDeepNet, a DL model that utilizes comprehensive temporal-spatial characterization, attention modules, and explainability techniques optimized for EEG signals. ADHDeepNet integrates feature extraction and refinement processes to enhance ADHD diagnosis. The model was trained and validated on a dataset of 121 participants (61 ADHD, 60 Healthy Controls), employing nested cross-validation for robust performance. The proposed two-stage methodology uses a 10-fold cross-subject validation strategy. Initially, each iteration optimizes the model's hyper-parameters with inner 2-fold cross-validation. Then, Additive Gaussian Noise (AGN) with various standard deviations and magnification levels is applied for data augmentation. ADHDeepNet achieved 100% sensitivity and 99.17% accuracy in classifying ADHD/HC subjects. To clarify model explainability and identify key brain regions and frequency bands for ADHD diagnosis, we analyzed the learned weights and activation patterns of the model's primary layers. Additionally, t-distributed Stochastic Neighbor Embedding (t-SNE) visualized high-dimensional data, aiding in interpreting the model's decisions. This study highlights the potential of DL and EEG in enhancing ADHD diagnosis accuracy and efficiency.

Toward Real-World BCI: CCSPNet, A Compact Subject-Independent Motor Imagery Framework

A conventional brain-computer interface (BCI) requires a complete data gathering, training, and calibration phase for each user before it can be used. This preliminary phase is time-consuming and should be done under the supervision of technical experts commonly in laboratories for the BCI to function properly. In recent years, a number of subject-independent (SI) BCIs have been developed. However, there are many problems preventing them from being used in real-world BCI applications. A lower accuracy than the subject-dependent (SD) approach and a relatively high run-time of models with a large number of model parameters are the most important ones. Therefore, a real-world BCI application would greatly benefit from a compact subject-independent BCI framework, ready to use immediately after the user puts it on, and suitable for low-power edge-computing and applications in the emerging area of internet of things (IoT). We propose a novel subject-independent BCI framework named CCSPNet (Convolutional Common Spatial Pattern Network) that is trained on the motor imagery (MI) paradigm of a large-scale EEG signals database consisting of 400 trials for every 54 subjects performing two-class hand-movement MI tasks. The proposed framework applies a wavelet kernel convolutional neural network (WKCNN) and a temporal convolutional neural network (TCNN) in order to represent and extract the diverse frequency behavior and spectral patterns of EEG signals. The convolutional layers outputs go through a CSP algorithm for class discrimination and spatial feature extraction. The number of CSP features is reduced by a dense neural network, and the final class label is determined by an LDA. The final SD and SI classification accuracies of the proposed framework match the best results obtained on the largest motor-imagery dataset present in the BCI literature, with 99.993 percent fewer model parameters.