Non-Sparse Regularization for Multiple Kernel Learning

Learning linear combinations of multiple kernels is an appealing strategy when the right choice of features is unknown. Previous approaches to multiple kernel learning (MKL) promote sparse kernel combinations to support interpretability and scalability. Unfortunately, this 1-norm MKL is rarely observed to outperform trivial baselines in practical applications. To allow for robust kernel mixtures, we generalize MKL to arbitrary norms. We devise new insights on the connection between several existing MKL formulations and develop two efficient interleaved optimization strategies for arbitrary norms, like p-norms with p>1. Empirically, we demonstrate that the interleaved optimization strategies are much faster compared to the commonly used wrapper approaches. A theoretical analysis and an experiment on controlled artificial data experiment sheds light on the appropriateness of sparse, non-sparse and $\ell_\infty$-norm MKL in various scenarios. Empirical applications of p-norm MKL to three real-world problems from computational biology show that non-sparse MKL achieves accuracies that go beyond the state-of-the-art.

The Feature Importance Ranking Measure

Most accurate predictions are typically obtained by learning machines with complex feature spaces (as e.g. induced by kernels). Unfortunately, such decision rules are hardly accessible to humans and cannot easily be used to gain insights about the application domain. Therefore, one often resorts to linear models in combination with variable selection, thereby sacrificing some predictive power for presumptive interpretability. Here, we introduce the Feature Importance Ranking Measure (FIRM), which by retrospective analysis of arbitrary learning machines allows to achieve both excellent predictive performance and superior interpretation. In contrast to standard raw feature weighting, FIRM takes the underlying correlation structure of the features into account. Thereby, it is able to discover the most relevant features, even if their appearance in the training data is entirely prevented by noise. The desirable properties of FIRM are investigated analytically and illustrated in simulations.