Large Multimodal Models (LMMs), harnessing the complementarity among diverse modalities, are often considered more robust than pure Language Large Models (LLMs); yet do LMMs know what they do not know? There are three key open questions remaining: (1) how to evaluate the uncertainty of diverse LMMs in a unified manner, (2) how to prompt LMMs to show its uncertainty, and (3) how to quantify uncertainty for downstream tasks. In an attempt to address these challenges, we introduce Uncertainty-o: (1) a model-agnostic framework designed to reveal uncertainty in LMMs regardless of their modalities, architectures, or capabilities, (2) an empirical exploration of multimodal prompt perturbations to uncover LMM uncertainty, offering insights and findings, and (3) derive the formulation of multimodal semantic uncertainty, which enables quantifying uncertainty from multimodal responses. Experiments across 18 benchmarks spanning various modalities and 10 LMMs (both open- and closed-source) demonstrate the effectiveness of Uncertainty-o in reliably estimating LMM uncertainty, thereby enhancing downstream tasks such as hallucination detection, hallucination mitigation, and uncertainty-aware Chain-of-Thought reasoning.