The integration of pattern-reconfigurable antennas into hybrid multiple-input multiple-output (MIMO) architectures presents a promising path toward high-efficiency and low-cost transceiver solutions. Pattern-reconfigurable antennas can dynamically steer per-antenna radiation patterns, enabling more efficient power utilization and interference suppression. In this work, we study a tri-hybrid MIMO architecture for multi-user communication that integrates digital, analog, and antenna-domain precoding using pattern-reconfigurable antennas. For characterizing the reconfigurability of antenna radiation patterns, we develop two models -- Model~I and Model~II. Model~I captures realistic hardware constraints through limited pattern selection, while Model~II explores the performance upper bound by assuming arbitrary pattern generation. Based on these models, we develop two corresponding tri-hybrid precoding algorithms grounded in the weighted minimum mean square error (WMMSE) framework, which alternately optimize the digital, analog, and antenna precoders under practical per-antenna power constraints. Realistic simulations conducted in ray-tracing generated environments are utilized to evaluate the proposed system and algorithms. The results demonstrate the significant potential of the considered tri-hybrid architecture in enhancing communication performance and hardware efficiency. However, they also reveal that the existing hardware is not yet capable of fully realizing these performance gains, underscoring the need for joint progress in antenna design and communication theory development.