In many signal processing applications, including communications, sonar, radar, and localization, a fundamental problem is the detection of a signal of interest in background noise, known as signal detection [1] [2]. A simple version of this problem is the detection of a signal of interest with unknown parameters in Additive White Gaussian Noise (AWGN). When the parameters defining the signal are not known, an optimal detector (in the Neyman-Pearson sense) does not exist. An upper bound on the performance of any detector is the matched filter, which implies perfect sample by sample knowledge of the signal of interest. In recent years Deep Neural Networks (DNNs) have proven to be very effective at hypothesis testing problems such as object detection and image classification. This paper examines the application of DNN-based approaches to the signal detection problem at the raw I/Q level and compares them to statistically based approaches as well as the Matched Filter. These methods aim to maximize the Probability of Detection Pd while maintaining a constant Probability of False Alarm PF A. Two Machine Learning (ML) algorithms are trained and assessed on this signal detection problem, across three signal of interest models. A model was also trained on a unified dataset and assessed across all signals of interest.