The recent surge in deploying extremely large antenna arrays is expected to play a vital role in future sixth generation wireless networks, enabling advanced radar target localization with enhanced angular and range resolution. This paper focuses on the promising technology of Dynamic Metasurface Antennas (DMAs), integrating numerous sub-wavelength-spaced metamaterials within a single aperture, and presents a novel framework for designing its analog reception beamforming weights with the goal to optimize sensing performance within a spatial Area of Interest (AoI), while simultaneously guaranteeing desired multi-user uplink communication performance. We derive the Cramer-Rao Bound (CRB) with DMA-based reception for both passive and active radar targets lying inside the AoI, which is then used as the optimization objective for configuring the discrete tunable phases of the metamaterials. Capitalizing on the DMA partially-connected architecture, we formulate the design problem as convex optimization and present both direct CRB minimization approaches and low complexity alternatives using a lower-bound approximation. Simulation results across various scenarios validate the effectiveness of the proposed framework, showing it consistently outperforms existing state-of-the-art methods.