Predicting interdependent load values in multiport scatterers is challenging due to high dimensionality and complex dependence between impedance and scattering ability, yet this prediction remains crucial for the design of communication and measurement systems. In this paper, we propose a two-stage cluster-then-predict framework for multiple load values prediction task in multiport scatterers. The proposed cluster-then-predict approach effectively captures the underlying functional relation between S-parameters and corresponding load impedances, achieving up to a 46% reduction in Root Mean Square Error (RMSE) compared to the baseline when applied to gradient boosting (GB). This improvement is consistent across various clustering and regression methods. Furthermore, we introduce the Real-world Unified Index (RUI), a metric for quantitative analysis of trade-offs among multiple metrics with conflicting objectives and different scales, suitable for performance assessment in realistic scenarios. Based on RUI, the combination of K-means clustering and k-nearest neighbors (KNN) is identified as the optimal setup for the analyzed multiport scatterer.