A System for Differentiation of Schizophrenia and Bipolar Disorder based on rsfMRI

Schizophrenia and bipolar disorder are debilitating psychiatric illnesses that can be challenging to diagnose accurately. The similarities between the diseases make it difficult to differentiate between them using traditional diagnostic tools. Recently, resting-state functional magnetic resonance imaging (rsfMRI) has emerged as a promising tool for the diagnosis of psychiatric disorders. This paper presents several methods for differentiating schizophrenia and bipolar disorder based on features extracted from rsfMRI data. The system that achieved the best results, uses 1D Convolutional Neural Networks to analyze patterns of Intrinsic Connectivity time courses obtained from rsfMRI and potentially identify biomarkers that distinguish between the two disorders. We evaluate the system's performance on a large dataset of patients with schizophrenia and bipolar disorder and demonstrate that the system achieves a 0.7078 Area Under Curve (AUC) score in differentiating patients with these disorders. Our results suggest that rsfMRI-based classification systems have great potential for improving the accuracy of psychiatric diagnoses and may ultimately lead to more effective treatments for patients with this disorder.

Macedonian Speech Synthesis for Assistive Technology Applications

Speech technology is becoming ever more ubiquitous with the advance of speech enabled devices and services. The use of speech synthesis in Augmentative and Alternative Communication tools, has facilitated inclusion of individuals with speech impediments allowing them to communicate with their surroundings using speech. Although there are numerous speech synthesis systems for the most spoken world languages, there is still a limited offer for smaller languages. We propose and compare three models built using parametric and deep learning techniques for Macedonian trained on a newly recorded corpus. We target low-resource edge deployment for Augmentative and Alternative Communication and assistive technologies, such as communication boards and screen readers. The listening test results show that parametric speech synthesis is as performant compared to the more advanced deep learning models. Since it also requires less resources, and offers full speech rate and pitch control, it is the preferred choice for building a Macedonian TTS system for this application scenario.