Three-Step Conditional Diffusion 3D Reconstruction for Light-Field Microscopy

Light-field microscopy (LFM) enables single-shot capture of multi-angular information from biological samples, supporting real-time volumetric imaging. However, traditional physics-based algorithms often suffer from limited spatial resolution, severe artifacts, and high computational costs. Existing learning-based methods improve inference efficiency but still face limitations in reconstruction accuracy and generalization capability. To address these challenges, this paper proposes a high-fidelity Three-Step Conditional Diffusion (TCD) 3D reconstruction method for LFM. Although conventional diffusion models have achieved remarkable success in generative modeling, their slow sampling process and the inherent trade-off between quality and efficiency hinder their application in real-time 3D imaging. We redesign the diffusion process through a deterministic three-step sampling strategy coupled with a lightweight conditional U-Net, establishing a new paradigm for fast and accurate volumetric reconstruction. Furthermore, an Inter-Class Detection (ICD) module is incorporated to identify out-of-distribution or anomalous inputs during inference, thereby enhancing model stability and reliability. Extensive experiments and cross-dataset evaluations demonstrate that TCD significantly outperforms state-of-the-art methods in both reconstruction fidelity and generalization, providing an efficient and practical 3D reconstruction solution for light-field microscopy.

Large-scale Traffic Signal Control Using a Novel Multi-Agent Reinforcement Learning

Finding the optimal signal timing strategy is a difficult task for the problem of large-scale traffic signal control (TSC). Multi-Agent Reinforcement Learning (MARL) is a promising method to solve this problem. However, there is still room for improvement in extending to large-scale problems and modeling the behaviors of other agents for each individual agent. In this paper, a new MARL, called Cooperative double Q-learning (Co-DQL), is proposed, which has several prominent features. It uses a highly scalable independent double Q-learning method based on double estimators and the UCB policy, which can eliminate the over-estimation problem existing in traditional independent Q-learning while ensuring exploration. It uses mean field approximation to model the interaction among agents, thereby making agents learn a better cooperative strategy. In order to improve the stability and robustness of the learning process, we introduce a new reward allocation mechanism and a local state sharing method. In addition, we analyze the convergence properties of the proposed algorithm. Co-DQL is applied on TSC and tested on a multi-traffic signal simulator. According to the results obtained on several traffic scenarios, Co- DQL outperforms several state-of-the-art decentralized MARL algorithms. It can effectively shorten the average waiting time of the vehicles in the whole road system.