Programmable magnetic soft robots with controlled locomotion and directional liquid cargo release

Magnetically programmable soft elastomers enable complex shape morphing and locomotion dynamics in small scale soft robots under external magnetic fields. Benefiting from their programmed deformation and wireless actuation capabilities, magnetic soft robots have emerged as promising platforms for targeted drug delivery, especially in human gastrointestinal tract. However, achieving controlled directional liquid cargo release toward desired tissue interface while preserving the encoded shape morphing and locomotion capabilities remain a significant challenge. Here, we report a new design strategy that employs an optimized magnetization profile to enable controlled directional release of aqueous cargo without compromising shape morphing and locomotion capabilities. Magnetic soft robots with a specific spatially distributed magnetization profile allow directional alignment of the release interface with the orientation of the external magnetic field. This orientation control ensures active alignment of the release interface toward the intestinal wall prior to drug release. An interconnected microporous elastomer is embedded within the robot for aqueous cargo storage, while a thin microcrystalline wax layer seals the release opening hole to isolate the stored liquid cargo from external environment during transport. Triggered release is achieved by mechanically rupturing the wax sealing layer under a higher magnitude external magnetic field. Controlled directional flipping, locomotion, and triggered release are decoupled through external magnetic field's direction and strength. The controlled directional release strategy reported here integrates directional targeted liquid cargo release, shape morphing, and locomotion, which establishes the groundwork for target drug delivery in gastrointestinal tract applications.

Membrane-based Acoustic Microrobots

Acoustic microrobots have emerged as a promising frontier for targeted drug delivery and minimally invasive medicine due to their high-power density and biocompatibility. Despite wide-ranging designs, conventional acoustic microrobots mostly rely on air microbubbles trapped within confined microcavities within the robot body, which suffer from limited operational longevity due to rapid gas dissolution and resultant shifts in resonance frequency. In this paper, we propose a robust, membrane-based acoustic microrobot that overcomes these limitations by employing a thin flexible Polydimethylsiloxane (PDMS) membrane bonded over confined microcavities for microstreaming. The introduced design physically prevents gas diffusion, ensuring stable performance over extended periods at high actuation voltages. We systematically characterized the membrane-based acoustic actuator longevity, demonstrating consistent streaming and propulsion for over 24 hours of continuous operation. In addition, by embedding magnetic microparticles into the structural body, these actuators were successfully employed as microswimmers with directional control using low-intensity (2 mT) external magnetic fields. Finally, we demonstrate the scalability of the proposed design architecture down to ~100 um. This membrane-based approach establishes a reliable framework for the development of high-endurance acoustic microactuators and microrobots capable of performing long-term tasks.

Shape-programmable Magnetic Soft Membranes for Mechanically Active Microchannels

The capability to encode spatially distinct magnetization patterns within soft materials enables remote control over complex deformations. This characteristic is especially important for microfluidic platforms, where limited dynamic control of channel boundaries and laminar flow conditions usually restrict fluid transport and interactions. The present study introduces a shape-programmable magnetic soft membrane actuator as an active microchannel component that can dynamically modulate its shape under magnetic fields and therefore the microfluidic environment. The membrane is magnetically programmed using a template-based approach, which allows it to be controllably deformed in the form of a sinusoid under the influence of an external magnetic field. The membrane's integration into a microchannel converts a passive channel wall into a dynamically changeable interface, allowing active fluid manipulation and enhancing micromixing in laminar flow conditions. The proposed approach establishes a versatile platform for wirelessly controlled deformable interfaces in next-generation microfluidic and lab-on-chip systems.