Simulations and Advancements in MRI-Guided Power-Driven Ferric Tools for Wireless Therapeutic Interventions

Designing a robotic system that functions effectively within the specific environment of a Magnetic Resonance Imaging (MRI) scanner requires solving numerous technical issues, such as maintaining the robot's precision and stability under strong magnetic fields. This research focuses on enhancing MRI's role in medical imaging, especially in its application to guide intravascular interventions using robot-assisted devices. A newly developed computational system is introduced, designed for seamless integration with the MRI scanner, including a computational unit and user interface. This system processes MR images to delineate the vascular network, establishing virtual paths and boundaries within vessels to prevent procedural damage. Key findings reveal the system's capability to create tailored magnetic field gradient patterns for device control, considering the vessel's geometry and safety norms, and adapting to different blood flow characteristics for finer navigation. Additionally, the system's modeling aspect assesses the safety and feasibility of navigating pre-set vascular paths. Conclusively, this system, based on the Qt framework and C/C++, with specialized software modules, represents a major step forward in merging imaging technology with robotic aid, significantly enhancing precision and safety in intravascular procedures.

A Novel Deep Learning Method for Segmenting the Left Ventricle in Cardiac Cine MRI

This research aims to develop a novel deep learning network, GBU-Net, utilizing a group-batch-normalized U-Net framework, specifically designed for the precise semantic segmentation of the left ventricle in short-axis cine MRI scans. The methodology includes a down-sampling pathway for feature extraction and an up-sampling pathway for detail restoration, enhanced for medical imaging. Key modifications include techniques for better contextual understanding crucial in cardiac MRI segmentation. The dataset consists of 805 left ventricular MRI scans from 45 patients, with comparative analysis using established metrics such as the dice coefficient and mean perpendicular distance. GBU-Net significantly improves the accuracy of left ventricle segmentation in cine MRI scans. Its innovative design outperforms existing methods in tests, surpassing standard metrics like the dice coefficient and mean perpendicular distance. The approach is unique in its ability to capture contextual information, often missed in traditional CNN-based segmentation. An ensemble of the GBU-Net attains a 97% dice score on the SunnyBrook testing dataset. GBU-Net offers enhanced precision and contextual understanding in left ventricle segmentation for surgical robotics and medical analysis.

Simulations of MRI Guided and Powered Ferric Applicators for Tetherless Delivery of Therapeutic Interventions

Magnetic Resonance Imaging (MRI) is a well-established modality for pre-operative planning and is also explored for intra-operative guidance of procedures such as intravascular interventions. Among the experimental robot-assisted technologies, the magnetic field gradients of the MRI scanner are used to power and maneuver ferromagnetic applicators for accessing sites in the patient's body via the vascular network. In this work, we propose a computational platform for preoperative planning and modeling of MRI-powered applicators inside blood vessels. This platform was implemented as a two-way data and command pipeline that links the MRI scanner, the computational core, and the operator. The platform first processes multi-slice MR data to extract the vascular bed and then fits a virtual corridor inside the vessel. This corridor serves as a virtual fixture (VF), a forbidden region for the applicators to avoid vessel perforation or collision. The geometric features of the vessel centerline, the VF, and MRI safety compliance (dB/dt, max available gradient) are then used to generate magnetic field gradient waveforms. Different blood flow profiles can be user-selected, and those parameters are used for modeling the applicator's maneuvering. The modeling module further generates cues about whether the selected vascular path can be safely maneuvered. Given future experimental studies that require a real-time operation, the platform was implemented on the Qt framework (C/C++) with software modules performing specific tasks running on dedicated threads: PID controller, generation of VF, generation of MR gradient waveforms.

Two Deep Learning Approaches for Automated Segmentation of Left Ventricle in Cine Cardiac MRI

Left ventricle (LV) segmentation is critical for clinical quantification and diagnosis of cardiac images. In this work, we propose two novel deep learning architectures called LNU-Net and IBU-Net for left ventricle segmentation from short-axis cine MRI images. LNU-Net is derived from layer normalization (LN) U-Net architecture, while IBU-Net is derived from the instance-batch normalized (IB) U-Net for medical image segmentation. The architectures of LNU-Net and IBU-Net have a down-sampling path for feature extraction and an up-sampling path for precise localization. We use the original U-Net as the basic segmentation approach and compared it with our proposed architectures. Both LNU-Net and IBU-Net have left ventricle segmentation methods: LNU-Net applies layer normalization in each convolutional block, while IBU-Net incorporates instance and batch normalization together in the first convolutional block and passes its result to the next layer. Our method incorporates affine transformations and elastic deformations for image data processing. Our dataset that contains 805 MRI images regarding the left ventricle from 45 patients is used for evaluation. We experimentally evaluate the results of the proposed approaches outperforming the dice coefficient and the average perpendicular distance than other state-of-the-art approaches.