Deep learning models have shown their superior performance in various vision tasks. However, the lack of precisely interpreting kernels in convolutional neural networks (CNNs) is becoming one main obstacle to wide applications of deep learning models in real scenarios. Although existing interpretation methods may find certain visual patterns which are associated with the activation of a specific kernel, those visual patterns may not be specific or comprehensive enough for interpretation of a specific activation of kernel of interest. In this paper, a simple yet effective optimization method is proposed to interpret the activation of any kernel of interest in CNN models. The basic idea is to simultaneously preserve the activation of the specific kernel and suppress the activation of all other kernels at the same layer. In this way, only visual information relevant to the activation of the specific kernel is remained in the input. Consistent visual information from multiple modified inputs would help users understand what kind of features are specifically associated with specific kernel. Comprehensive evaluation shows that the proposed method can help better interpret activation of specific kernels than widely used methods, even when two kernels have very similar activation regions from the same input image.