Could We Generate Cytology Images from Histopathology Images? An Empirical Study

Automation in medical imaging is quite challenging due to the unavailability of annotated datasets and the scarcity of domain experts. In recent years, deep learning techniques have solved some complex medical imaging tasks like disease classification, important object localization, segmentation, etc. However, most of the task requires a large amount of annotated data for their successful implementation. To mitigate the shortage of data, different generative models are proposed for data augmentation purposes which can boost the classification performances. For this, different synthetic medical image data generation models are developed to increase the dataset. Unpaired image-to-image translation models here shift the source domain to the target domain. In the breast malignancy identification domain, FNAC is one of the low-cost low-invasive modalities normally used by medical practitioners. But availability of public datasets in this domain is very poor. Whereas, for automation of cytology images, we need a large amount of annotated data. Therefore synthetic cytology images are generated by translating breast histopathology samples which are publicly available. In this study, we have explored traditional image-to-image transfer models like CycleGAN, and Neural Style Transfer. Further, it is observed that the generated cytology images are quite similar to real breast cytology samples by measuring FID and KID scores.

Fuzzy Rank-based Late Fusion Technique for Cytology image Segmentation

Cytology image segmentation is quite challenging due to its complex cellular structure and multiple overlapping regions. On the other hand, for supervised machine learning techniques, we need a large amount of annotated data, which is costly. In recent years, late fusion techniques have given some promising performances in the field of image classification. In this paper, we have explored a fuzzy-based late fusion techniques for cytology image segmentation. This fusion rule integrates three traditional semantic segmentation models UNet, SegNet, and PSPNet. The technique is applied on two cytology image datasets, i.e., cervical cytology(HErlev) and breast cytology(JUCYT-v1) image datasets. We have achieved maximum MeanIoU score 84.27% and 83.79% on the HErlev dataset and JUCYT-v1 dataset after the proposed late fusion technique, respectively which are better than that of the traditional fusion rules such as average probability, geometric mean, Borda Count, etc. The codes of the proposed model are available on GitHub.