DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentation

Weakly supervised semantic segmentation (WSSS) in histopathology seeks to reduce annotation cost by learning from image-level labels, yet it remains limited by inter-class homogeneity, intra-class heterogeneity, and the region-shrinkage effect of CAM-based supervision. We propose a simple and effective prototype-driven framework that leverages vision-language alignment to improve region discovery under weak supervision. Our method integrates CoOp-style learnable prompt tuning to generate text-based prototypes and combines them with learnable image prototypes, forming a dual-modal prototype bank that captures both semantic and appearance cues. To address oversmoothing in ViT representations, we incorporate a multi-scale pyramid module that enhances spatial precision and improves localization quality. Experiments on the BCSS-WSSS benchmark show that our approach surpasses existing state-of-the-art methods, and detailed analyses demonstrate the benefits of text description diversity, context length, and the complementary behavior of text and image prototypes. These results highlight the effectiveness of jointly leveraging textual semantics and visual prototype learning for WSSS in digital pathology.

X-ray Fluoroscopy Guided Localization and Steering of Medical Microrobots through Virtual Enhancement

In developing medical interventions using untethered milli- and microrobots, ensuring safety and effectiveness relies on robust methods for detection, real-time tracking, and precise localization within the body. However, the inherent non-transparency of the human body poses a significant obstacle, limiting robot detection primarily to specialized imaging systems such as X-ray fluoroscopy, which often lack crucial anatomical details. Consequently, the robot operator (human or machine) would encounter severe challenges in accurately determining the location of the robot and steering its motion. This study explores the feasibility of circumventing this challenge by creating a simulation environment that contains the precise digital replica (virtual twin) of a model microrobot operational workspace. Synchronizing coordinate systems between the virtual and real worlds and continuously integrating microrobot position data from the image stream into the virtual twin allows the microrobot operator to control navigation in the virtual world. We validate this concept by demonstrating the tracking and steering of a mobile magnetic robot in confined phantoms with high temporal resolution (< 100 ms, with an average of ~20 ms) visual feedback. Additionally, our object detection-based localization approach offers the potential to reduce overall patient exposure to X-ray doses during continuous microrobot tracking without compromising tracking accuracy. Ultimately, we address a critical gap in developing image-guided remote interventions with untethered medical microrobots, particularly for near-future applications in animal models and human patients.