Lifelong Whole Slide Image Analysis: Online Vision-Language Adaptation and Past-to-Present Gradient Distillation

Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges. Given that WSIs are gigapixels in size, they present difficulties in terms of storage, processing, and model training. Therefore, it is essential to develop lifelong learning approaches for WSI analysis. In scenarios where slides are distributed across multiple institutes, we aim to leverage them to develop a unified online model as a computational tool for cancer diagnosis in clinical and hospital settings. In this study, we introduce ADaFGrad, a method designed to enhance lifelong learning for whole-slide image (WSI) analysis. First, we leverage pathology vision-language foundation models to develop a framework that enables interaction between a slide's regional tissue features and a predefined text-based prototype buffer. Additionally, we propose a gradient-distillation mechanism that mimics the gradient of a logit with respect to the classification-head parameters across past and current iterations in a continual-learning setting. We construct a sequence of six TCGA datasets for training and evaluation. Experimental results show that ADaFGrad outperforms both state-of-the-art WSI-specific and conventional continual-learning methods after only a few training epochs, exceeding them by up to +5.068% in the class-incremental learning scenario while exhibiting the least forgetting (i.e., retaining the most knowledge from previous tasks). Moreover, ADaFGrad surpasses its baseline by as much as +40.084% in accuracy, further demonstrating the effectiveness of the proposed modules.

ZeroSlide: Is Zero-Shot Classification Adequate for Lifelong Learning in Whole-Slide Image Analysis in the Era of Pathology Vision-Language Foundation Models?

Lifelong learning for whole slide images (WSIs) poses the challenge of training a unified model to perform multiple WSI-related tasks, such as cancer subtyping and tumor classification, in a distributed, continual fashion. This is a practical and applicable problem in clinics and hospitals, as WSIs are large, require storage, processing, and transfer time. Training new models whenever new tasks are defined is time-consuming. Recent work has applied regularization- and rehearsal-based methods to this setting. However, the rise of vision-language foundation models that align diagnostic text with pathology images raises the question: are these models alone sufficient for lifelong WSI learning using zero-shot classification, or is further investigation into continual learning strategies needed to improve performance? To our knowledge, this is the first study to compare conventional continual-learning approaches with vision-language zero-shot classification for WSIs. Our source code and experimental results will be available soon.

Exploring the Limitations of Kolmogorov-Arnold Networks in Classification: Insights to Software Training and Hardware Implementation

Kolmogorov-Arnold Networks (KANs), a novel type of neural network, have recently gained popularity and attention due to the ability to substitute multi-layer perceptions (MLPs) in artificial intelligence (AI) with higher accuracy and interoperability. However, KAN assessment is still limited and cannot provide an in-depth analysis of a specific domain. Furthermore, no study has been conducted on the implementation of KANs in hardware design, which would directly demonstrate whether KANs are truly superior to MLPs in practical applications. As a result, in this paper, we focus on verifying KANs for classification issues, which are a common but significant topic in AI using four different types of datasets. Furthermore, the corresponding hardware implementation is considered using the Vitis high-level synthesis (HLS) tool. To the best of our knowledge, this is the first article to implement hardware for KAN. The results indicate that KANs cannot achieve more accuracy than MLPs in high complex datasets while utilizing substantially higher hardware resources. Therefore, MLP remains an effective approach for achieving accuracy and efficiency in software and hardware implementation.