A Strictly Bounded Deep Network for Unpaired Cyclic Translation of Medical Images

Medical image translation is an ill-posed problem. Unlike existing paired unbounded unidirectional translation networks, in this paper, we consider unpaired medical images and provide a strictly bounded network that yields a stable bidirectional translation. We propose a patch-level concatenated cyclic conditional generative adversarial network (pCCGAN) embedded with adaptive dictionary learning. It consists of two cyclically connected CGANs of 47 layers each; where both generators (each of 32 layers) are conditioned with concatenation of alternate unpaired patches from input and target modality images (not ground truth) of the same organ. The key idea is to exploit cross-neighborhood contextual feature information that bounds the translation space and boosts generalization. The generators are further equipped with adaptive dictionaries learned from the contextual patches to reduce possible degradation. Discriminators are 15-layer deep networks that employ minimax function to validate the translated imagery. A combined loss function is formulated with adversarial, non-adversarial, forward-backward cyclic, and identity losses that further minimize the variance of the proposed learning machine. Qualitative, quantitative, and ablation analysis show superior results on real CT and MRI.

An unsupervised deep learning framework for medical image denoising

Medical image acquisition is often intervented by unwanted noise that corrupts the information content. This paper introduces an unsupervised medical image denoising technique that learns noise characteristics from the available images and constructs denoised images. It comprises of two blocks of data processing, viz., patch-based dictionaries that indirectly learn the noise and residual learning (RL) that directly learns the noise. The model is generalized to account for both 2D and 3D images considering different medical imaging instruments. The images are considered one-by-one from the stack of MRI/CT images as well as the entire stack is considered, and decomposed into overlapping image/volume patches. These patches are given to the patch-based dictionary learning to learn noise characteristics via sparse representation while given to the RL part to directly learn the noise properties. K-singular value decomposition (K-SVD) algorithm for sparse representation is used for training patch-based dictionaries. On the other hand, residue in the patches is trained using the proposed deep residue network. Iterating on these two parts, an optimum noise characterization for each image/volume patch is captured and in turn it is subtracted from the available respective image/volume patch. The obtained denoised image/volume patches are finally assembled to a denoised image or 3D stack. We provide an analysis of the proposed approach with other approaches. Experiments on MRI/CT datasets are run on a GPU-based supercomputer and the comparative results show that the proposed algorithm preserves the critical information in the images as well as improves the visual quality of the images.