FastOMOP: A Foundational Architecture for Reliable Agentic Real-World Evidence Generation on OMOP CDM data

The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM), maintained by the Observational Health Data Sciences and Informatics (OHDSI) collaboration, enabled the harmonisation of electronic health records data of nearly one billion patients in 83 countries. Yet generating real-world evidence (RWE) from these repositories remains a manual process requiring clinical, epidemiological and technical expertise. LLMs and multi-agent systems have shown promise for clinical tasks, but RWE automation exposes a fundamental challenge: agentic systems introduce emergent behaviours, coordination failures and safety risks that existing approaches fail to govern. No infrastructure exists to ensure agentic RWE generation is flexible, safe and auditable across the lifecycle. We introduce FastOMOP, an open-source multi-agent architecture that addresses this gap by separating three infrastructure layers, governance, observability and orchestration, from pluggable agent-teams. Governance is enforced at the process boundary through deterministic validation independent of agent reasoning, ensuring no compromised or hallucinating agent can bypass safety controls. Agent teams for phenotyping, study design and statistical analysis inherit these guarantees through controlled tool exposure. We validated FastOMOP using a natural-language-to-SQL agent team across three OMOP CDM datasets: synthetic data from Synthea, MIMIC-IV and a real-world NHS dataset from Lancashire Teaching Hospitals (IDRIL). FastOMOP achieved reliability scores of 0.84-0.94 with perfect adversarial and out-of-scope block rates, demonstrating process-boundary governance delivers safety guarantees independent of model choice. These results indicate that the reliability gap in RWE deployment is architectural rather than model capability, and establish FastOMOP as a governed architecture for progressive RWE automation.

Personalised Feedback Framework for Online Education Programmes Using Generative AI

AI tools, particularly large language modules, have recently proven their effectiveness within learning management systems and online education programmes. As feedback continues to play a crucial role in learning and assessment in schools, educators must carefully customise the use of AI tools in order to optimally support students in their learning journey. Efforts to improve educational feedback systems have seen numerous attempts reflected in the research studies but mostly have been focusing on qualitatively benchmarking AI feedback against human-generated feedback. This paper presents an exploration of an alternative feedback framework which extends the capabilities of ChatGPT by integrating embeddings, enabling a more nuanced understanding of educational materials and facilitating topic-targeted feedback for quiz-based assessments. As part of the study, we proposed and developed a proof of concept solution, achieving an efficacy rate of 90% and 100% for open-ended and multiple-choice questions, respectively. The results showed that our framework not only surpasses expectations but also rivals human narratives, highlighting the potential of AI in revolutionising educational feedback mechanisms.