Anomaly Detection-Inspired Few-Shot Medical Image Segmentation Through Self-Supervision With Supervoxels

Recent work has shown that label-efficient few-shot learning through self-supervision can achieve promising medical image segmentation results. However, few-shot segmentation models typically rely on prototype representations of the semantic classes, resulting in a loss of local information that can degrade performance. This is particularly problematic for the typically large and highly heterogeneous background class in medical image segmentation problems. Previous works have attempted to address this issue by learning additional prototypes for each class, but since the prototypes are based on a limited number of slices, we argue that this ad-hoc solution is insufficient to capture the background properties. Motivated by this, and the observation that the foreground class (e.g., one organ) is relatively homogeneous, we propose a novel anomaly detection-inspired approach to few-shot medical image segmentation in which we refrain from modeling the background explicitly. Instead, we rely solely on a single foreground prototype to compute anomaly scores for all query pixels. The segmentation is then performed by thresholding these anomaly scores using a learned threshold. Assisted by a novel self-supervision task that exploits the 3D structure of medical images through supervoxels, our proposed anomaly detection-inspired few-shot medical image segmentation model outperforms previous state-of-the-art approaches on two representative MRI datasets for the tasks of abdominal organ segmentation and cardiac segmentation.

Demonstrating The Risk of Imbalanced Datasets in Chest X-ray Image-based Diagnostics by Prototypical Relevance Propagation

The recent trend of integrating multi-source Chest X-Ray datasets to improve automated diagnostics raises concerns that models learn to exploit source-specific correlations to improve performance by recognizing the source domain of an image rather than the medical pathology. We hypothesize that this effect is enforced by and leverages label-imbalance across the source domains, i.e, prevalence of a disease corresponding to a source. Therefore, in this work, we perform a thorough study of the effect of label-imbalance in multi-source training for the task of pneumonia detection on the widely used ChestX-ray14 and CheXpert datasets. The results highlight and stress the importance of using more faithful and transparent self-explaining models for automated diagnosis, thus enabling the inherent detection of spurious learning. They further illustrate that this undesirable effect of learning spurious correlations can be reduced considerably when ensuring label-balanced source domain datasets.

RELAX: Representation Learning Explainability

Despite the significant improvements that representation learning via self-supervision has led to when learning from unlabeled data, no methods exist that explain what influences the learned representation. We address this need through our proposed approach, RELAX, which is the first approach for attribution-based explanations of representations. Our approach can also model the uncertainty in its explanations, which is essential to produce trustworthy explanations. RELAX explains representations by measuring similarities in the representation space between an input and masked out versions of itself, providing intuitive explanations and significantly outperforming the gradient-based baseline. We provide theoretical interpretations of RELAX and conduct a novel analysis of feature extractors trained using supervised and unsupervised learning, providing insights into different learning strategies. Finally, we illustrate the usability of RELAX in multi-view clustering and highlight that incorporating uncertainty can be essential for providing low-complexity explanations, taking a crucial step towards explaining representations.

Multi-modal land cover mapping of remote sensing images using pyramid attention and gated fusion networks

Multi-modality data is becoming readily available in remote sensing (RS) and can provide complementary information about the Earth's surface. Effective fusion of multi-modal information is thus important for various applications in RS, but also very challenging due to large domain differences, noise, and redundancies. There is a lack of effective and scalable fusion techniques for bridging multiple modality encoders and fully exploiting complementary information. To this end, we propose a new multi-modality network (MultiModNet) for land cover mapping of multi-modal remote sensing data based on a novel pyramid attention fusion (PAF) module and a gated fusion unit (GFU). The PAF module is designed to efficiently obtain rich fine-grained contextual representations from each modality with a built-in cross-level and cross-view attention fusion mechanism, and the GFU module utilizes a novel gating mechanism for early merging of features, thereby diminishing hidden redundancies and noise. This enables supplementary modalities to effectively extract the most valuable and complementary information for late feature fusion. Extensive experiments on two representative RS benchmark datasets demonstrate the effectiveness, robustness, and superiority of the MultiModNet for multi-modal land cover classification.

Discriminative Multimodal Learning via Conditional Priors in Generative Models

Deep generative models with latent variables have been used lately to learn joint representations and generative processes from multi-modal data. These two learning mechanisms can, however, conflict with each other and representations can fail to embed information on the data modalities. This research studies the realistic scenario in which all modalities and class labels are available for model training, but where some modalities and labels required for downstream tasks are missing. We show, in this scenario, that the variational lower bound limits mutual information between joint representations and missing modalities. We, to counteract these problems, introduce a novel conditional multi-modal discriminative model that uses an informative prior distribution and optimizes a likelihood-free objective function that maximizes mutual information between joint representations and missing modalities. Extensive experimentation shows the benefits of the model we propose, the empirical results showing that our model achieves state-of-the-art results in representative problems such as downstream classification, acoustic inversion and annotation generation.

This looks more like that: Enhancing Self-Explaining Models by Prototypical Relevance Propagation

Current machine learning models have shown high efficiency in solving a wide variety of real-world problems. However, their black box character poses a major challenge for the understanding and traceability of the underlying decision-making strategies. As a remedy, many post-hoc explanation and self-explanatory methods have been developed to interpret the models' behavior. These methods, in addition, enable the identification of artifacts that can be learned by the model as class-relevant features. In this work, we provide a detailed case study of the self-explaining network, ProtoPNet, in the presence of a spectrum of artifacts. Accordingly, we identify the main drawbacks of ProtoPNet, especially, its coarse and spatially imprecise explanations. We address these limitations by introducing Prototypical Relevance Propagation (PRP), a novel method for generating more precise model-aware explanations. Furthermore, in order to obtain a clean dataset, we propose to use multi-view clustering strategies for segregating the artifact images using the PRP explanations, thereby suppressing the potential artifact learning in the models.

On the Use of Time Series Kernel and Dimensionality Reduction to Identify the Acquisition of Antimicrobial Multidrug Resistance in the Intensive Care Unit

The acquisition of Antimicrobial Multidrug Resistance (AMR) in patients admitted to the Intensive Care Units (ICU) is a major global concern. This study analyses data in the form of multivariate time series (MTS) from 3476 patients recorded at the ICU of University Hospital of Fuenlabrada (Madrid) from 2004 to 2020. 18\% of the patients acquired AMR during their stay in the ICU. The goal of this paper is an early prediction of the development of AMR. Towards that end, we leverage the time-series cluster kernel (TCK) to learn similarities between MTS. To evaluate the effectiveness of TCK as a kernel, we applied several dimensionality reduction techniques for visualization and classification tasks. The experimental results show that TCK allows identifying a group of patients that acquire the AMR during the first 48 hours of their ICU stay, and it also provides good classification capabilities.

Reconsidering Representation Alignment for Multi-view Clustering

Aligning distributions of view representations is a core component of today's state of the art models for deep multi-view clustering. However, we identify several drawbacks with na\"ively aligning representation distributions. We demonstrate that these drawbacks both lead to less separable clusters in the representation space, and inhibit the model's ability to prioritize views. Based on these observations, we develop a simple baseline model for deep multi-view clustering. Our baseline model avoids representation alignment altogether, while performing similar to, or better than, the current state of the art. We also expand our baseline model by adding a contrastive learning component. This introduces a selective alignment procedure that preserves the model's ability to prioritize views. Our experiments show that the contrastive learning component enhances the baseline model, improving on the current state of the art by a large margin on several datasets.

Measuring Dependence with Matrix-based Entropy Functional

Measuring the dependence of data plays a central role in statistics and machine learning. In this work, we summarize and generalize the main idea of existing information-theoretic dependence measures into a higher-level perspective by the Shearer's inequality. Based on our generalization, we then propose two measures, namely the matrix-based normalized total correlation ($T_\alpha^*$) and the matrix-based normalized dual total correlation ($D_\alpha^*$), to quantify the dependence of multiple variables in arbitrary dimensional space, without explicit estimation of the underlying data distributions. We show that our measures are differentiable and statistically more powerful than prevalent ones. We also show the impact of our measures in four different machine learning problems, namely the gene regulatory network inference, the robust machine learning under covariate shift and non-Gaussian noises, the subspace outlier detection, and the understanding of the learning dynamics of convolutional neural networks (CNNs), to demonstrate their utilities, advantages, as well as implications to those problems. Code of our dependence measure is available at: https://bit.ly/AAAI-dependence

Joint Optimization of an Autoencoder for Clustering and Embedding

Incorporating k-means-like clustering techniques into (deep) autoencoders constitutes an interesting idea as the clustering may exploit the learned similarities in the embedding to compute a non-linear grouping of data at-hand. Unfortunately, the resulting contributions are often limited by ad-hoc choices, decoupled optimization problems and other issues. We present a theoretically-driven deep clustering approach that does not suffer from these limitations and allows for joint optimization of clustering and embedding. The network in its simplest form is derived from a Gaussian mixture model and can be incorporated seamlessly into deep autoencoders for state-of-the-art performance.