Two-Steps Neural Networks for an Automated Cerebrovascular Landmark Detection

Intracranial aneurysms (ICA) commonly occur in specific segments of the Circle of Willis (CoW), primarily, onto thirteen major arterial bifurcations. An accurate detection of these critical landmarks is necessary for a prompt and efficient diagnosis. We introduce a fully automated landmark detection approach for CoW bifurcations using a two-step neural networks process. Initially, an object detection network identifies regions of interest (ROIs) proximal to the landmark locations. Subsequently, a modified U-Net with deep supervision is exploited to accurately locate the bifurcations. This two-step method reduces various problems, such as the missed detections caused by two landmarks being close to each other and having similar visual characteristics, especially when processing the complete MRA Time-of-Flight (TOF). Additionally, it accounts for the anatomical variability of the CoW, which affects the number of detectable landmarks per scan. We assessed the effectiveness of our approach using two cerebral MRA datasets: our In-House dataset which had varying numbers of landmarks, and a public dataset with standardized landmark configuration. Our experimental results demonstrate that our method achieves the highest level of performance on a bifurcation detection task.

Building a Synthetic Vascular Model: Evaluation in an Intracranial Aneurysms Detection Scenario

We hereby present a full synthetic model, able to mimic the various constituents of the cerebral vascular tree, including the cerebral arteries, bifurcations and intracranial aneurysms. This model intends to provide a substantial dataset of brain arteries which could be used by a 3D convolutional neural network to efficiently detect Intra-Cranial Aneurysms. The cerebral aneurysms most often occur on a particular structure of the vascular tree named the Circle of Willis. Various studies have been conducted to detect and monitor the aneurysms and those based on Deep Learning achieve the best performance. Specifically, in this work, we propose a full synthetic 3D model able to mimic the brain vasculature as acquired by Magnetic Resonance Angiography, Time Of Flight principle. Among the various MRI modalities, this latter allows for a good rendering of the blood vessels and is non-invasive. Our model has been designed to simultaneously mimic the arteries' geometry, the aneurysm shape, and the background noise. The vascular tree geometry is modeled thanks to an interpolation with 3D Spline functions, and the statistical properties of the background noise is collected from angiography acquisitions and reproduced within the model. In this work, we thoroughly describe the synthetic vasculature model, we build up a neural network designed for aneurysm segmentation and detection, finally, we carry out an in-depth evaluation of the performance gap gained thanks to the synthetic model data augmentation.

A vascular synthetic model for improved aneurysm segmentation and detection via Deep Neural Networks

We hereby present a full synthetic model, able to mimic the various constituents of the cerebral vascular tree: the cerebral arteries, the bifurcations and the intracranial aneurysms. By building this model, our goal was to provide a substantial dataset of brain arteries which could be used by a 3D Convolutional Neural Network (CNN) to either segment or detect/recognize various vascular diseases (such as artery dissection/thrombosis) or even some portions of the cerebral vasculature, such as the bifurcations or aneurysms. In this study, we will particularly focus on Intra-Cranial Aneurysm (ICA) detection and segmentation. The cerebral aneurysms most often occur on a particular structure of the vascular tree named the Circle of Willis. Various studies have been conducted to detect and monitor the ICAs and those based on Deep Learning (DL) achieve the best performances. Specifically, in this work, we propose a full synthetic 3D model able to mimic the brain vasculature as acquired by Magnetic Resonance Angiography (MRA), and more particularly the Time Of Flight (TOF) principle. Among the various MRI modalities, the MRA-TOF allows to have a relatively good rendering of the blood vessels and is non-invasive (no contrast liquid injection). Our model has been designed to simultaneously mimic the arteries geometry, the ICA shape and the background noise. The geometry of the vascular tree is modeled thanks to an interpolation with 3D Spline functions, and the statistical properties of the background MRI noise is collected from MRA acquisitions and reproduced within the model. In this work, we thoroughly describe the synthetic vasculature model, we build up a neural network designed for ICA segmentation and detection, and finally, we carry out an in-depth evaluation of the performance gap gained thanks to the synthetic model data augmentation.

Using deep learning for an automatic detection and classification of the vascular bifurcations along the Circle of Willis

Most of the intracranial aneurysms (ICA) occur on a specific portion of the cerebral vascular tree named the Circle of Willis (CoW). More particularly, they mainly arise onto fifteen of the major arterial bifurcations constituting this circular structure. Hence, for an efficient and timely diagnosis it is critical to develop some methods being able to accurately recognize each Bifurcation of Interest (BoI). Indeed, an automatic extraction of the bifurcations presenting the higher risk of developing an ICA would offer the neuroradiologists a quick glance at the most alarming areas. Due to the recent efforts on Artificial Intelligence, Deep Learning turned out to be the best performing technology for many pattern recognition tasks. Moreover, various methods have been particularly designed for medical image analysis purposes. This study intends to assist the neuroradiologists to promptly locate any bifurcation presenting a high risk of ICA occurrence. It can be seen as a Computer Aided Diagnosis scheme, where the Artificial Intelligence facilitates the access to the regions of interest within the MRI. In this work, we propose a method for a fully automatic detection and recognition of the bifurcations of interest forming the Circle of Willis. Several neural networks architectures have been tested, and we thoroughly evaluate the bifurcation recognition rate.