Towards Learning Contrast Kinetics with Multi-Condition Latent Diffusion Models

Contrast agents in dynamic contrast enhanced magnetic resonance imaging allow to localize tumors and observe their contrast kinetics, which is essential for cancer characterization and respective treatment decision-making. However, contrast agent administration is not only associated with adverse health risks, but also restricted for patients during pregnancy, and for those with kidney malfunction, or other adverse reactions. With contrast uptake as key biomarker for lesion malignancy, cancer recurrence risk, and treatment response, it becomes pivotal to reduce the dependency on intravenous contrast agent administration. To this end, we propose a multi-conditional latent diffusion model capable of acquisition time-conditioned image synthesis of DCE-MRI temporal sequences. To evaluate medical image synthesis, we additionally propose and validate the Fr\'echet radiomics distance as an image quality measure based on biomarker variability between synthetic and real imaging data. Our results demonstrate our method's ability to generate realistic multi-sequence fat-saturated breast DCE-MRI and uncover the emerging potential of deep learning based contrast kinetics simulation. We publicly share our accessible codebase at https://github.com/RichardObi/ccnet.

Punjabi Language Interface to Database: a brief review

Unlike most user-computer interfaces, a natural language interface allows users to communicate fluently with a computer system with very little preparation. Databases are often hard to use in cooperating with the users because of their rigid interface. A good NLIDB allows a user to enter commands and ask questions in native language and then after interpreting respond to the user in native language. For a large number of applications requiring interaction between humans and the computer systems, it would be convenient to provide the end-user friendly interface. Punjabi language interface to database would proof fruitful to native people of Punjab, as it provides ease to them to use various e-governance applications like Punjab Sewa, Suwidha, Online Public Utility Forms, Online Grievance Cell, Land Records Management System,legacy matters, e-District, agriculture, etc. Punjabi is the mother tongue of more than 110 million people all around the world. According to available information, Punjabi ranks 10th from top out of a total of 6,900 languages recognized internationally by the United Nations. This paper covers a brief overview of the Natural language interface to database, its different components, its advantages, disadvantages, approaches and techniques used. The paper ends with the work done on Punjabi language interface to database and future enhancements that can be done.