A Multi-Centric Anthropomorphic 3D CT Phantom-Based Benchmark Dataset for Harmonization

Artificial intelligence (AI) has introduced numerous opportunities for human assistance and task automation in medicine. However, it suffers from poor generalization in the presence of shifts in the data distribution. In the context of AI-based computed tomography (CT) analysis, significant data distribution shifts can be caused by changes in scanner manufacturer, reconstruction technique or dose. AI harmonization techniques can address this problem by reducing distribution shifts caused by various acquisition settings. This paper presents an open-source benchmark dataset containing CT scans of an anthropomorphic phantom acquired with various scanners and settings, which purpose is to foster the development of AI harmonization techniques. Using a phantom allows fixing variations attributed to inter- and intra-patient variations. The dataset includes 1378 image series acquired with 13 scanners from 4 manufacturers across 8 institutions using a harmonized protocol as well as several acquisition doses. Additionally, we present a methodology, baseline results and open-source code to assess image- and feature-level stability and liver tissue classification, promoting the development of AI harmonization strategies.

A Multi-Objective Evaluation Framework for Analyzing Utility-Fairness Trade-Offs in Machine Learning Systems

The evaluation of fairness models in Machine Learning involves complex challenges, such as defining appropriate metrics, balancing trade-offs between utility and fairness, and there are still gaps in this stage. This work presents a novel multi-objective evaluation framework that enables the analysis of utility-fairness trade-offs in Machine Learning systems. The framework was developed using criteria from Multi-Objective Optimization that collect comprehensive information regarding this complex evaluation task. The assessment of multiple Machine Learning systems is summarized, both quantitatively and qualitatively, in a straightforward manner through a radar chart and a measurement table encompassing various aspects such as convergence, system capacity, and diversity. The framework's compact representation of performance facilitates the comparative analysis of different Machine Learning strategies for decision-makers, in real-world applications, with single or multiple fairness requirements. The framework is model-agnostic and flexible to be adapted to any kind of Machine Learning systems, that is, black- or white-box, any kind and quantity of evaluation metrics, including multidimensional fairness criteria. The functionality and effectiveness of the proposed framework is shown with different simulations, and an empirical study conducted on a real-world dataset with various Machine Learning systems.