AI-guided stimuli discovery and generation to optimize facial emotion perception studies in autism

Understanding perceptual differences between autistic and neurotypical adults requires behavioral assays that are sensitive, reliable, and mechanistically informative. Facial emotion perception is a useful test case because group differences have been reported, but findings vary across studies. Here we show that this variability may reflect image-level sparsity: autistic-neurotypical differences in emotion judgments were concentrated in a small subset of diagnostic facial expressions rather than spread uniformly across stimuli. We trained population-specific artificial neural network models to predict image-level judgments for autistic and neurotypical participants, then used these models to select novel faces predicted to maximize group separation. In an independent cohort, model-selected images produced larger behavioral differences than matched random images. We then used the same models with a generative adversarial network to transform diagnostic images toward greater predicted group agreement. In phenotype-matched validation, synthesized images reduced behavioral separation relative to their matched originals. These results establish a model-guided framework for discovering and transforming stimuli that reveal population-specific perceptual differences. More broadly, they show how behavioral phenotyping can move beyond averaging across fixed stimulus sets toward optimized assays that identify the conditions under which neurodivergent perception diverges or converges.

Machine vision for vial positioning detection toward the safe automation of material synthesis

Although robot-based automation in chemistry laboratories can accelerate the material development process, surveillance-free environments may lead to dangerous accidents primarily due to machine control errors. Object detection techniques can play vital roles in addressing these safety issues; however, state-of-the-art detectors, including single-shot detector (SSD) models, suffer from insufficient accuracy in environments involving complex and noisy scenes. With the aim of improving safety in a surveillance-free laboratory, we report a novel deep learning (DL)-based object detector, namely, DenseSSD. For the foremost and frequent problem of detecting vial positions, DenseSSD achieved a mean average precision (mAP) over 95% based on a complex dataset involving both empty and solution-filled vials, greatly exceeding those of conventional detectors; such high precision is critical to minimizing failure-induced accidents. Additionally, DenseSSD was observed to be highly insensitive to the environmental changes, maintaining its high precision under the variations of solution colors or testing view angles. The robustness of DenseSSD would allow the utilized equipment settings to be more flexible. This work demonstrates that DenseSSD is useful for enhancing safety in an automated material synthesis environment, and it can be extended to various applications where high detection accuracy and speed are both needed.