LLM Novice Uplift on Dual-Use, In Silico Biology Tasks

Large language models (LLMs) perform increasingly well on biology benchmarks, but it remains unclear whether they uplift novice users -- i.e., enable humans to perform better than with internet-only resources. This uncertainty is central to understanding both scientific acceleration and dual-use risk. We conducted a multi-model, multi-benchmark human uplift study comparing novices with LLM access versus internet-only access across eight biosecurity-relevant task sets. Participants worked on complex problems with ample time (up to 13 hours for the most involved tasks). We found that LLM access provided substantial uplift: novices with LLMs were 4.16 times more accurate than controls (95% CI [2.63, 6.87]). On four benchmarks with available expert baselines (internet-only), novices with LLMs outperformed experts on three of them. Perhaps surprisingly, standalone LLMs often exceeded LLM-assisted novices, indicating that users were not eliciting the strongest available contributions from the LLMs. Most participants (89.6%) reported little difficulty obtaining dual-use-relevant information despite safeguards. Overall, LLMs substantially uplift novices on biological tasks previously reserved for trained practitioners, underscoring the need for sustained, interactive uplift evaluations alongside traditional benchmarks.

SecureGate: Learning When to Reveal PII Safely via Token-Gated Dual-Adapters for Federated LLMs

Federated learning (FL) enables collaborative training across organizational silos without sharing raw data, making it attractive for privacy-sensitive applications. With the rapid adoption of large language models (LLMs), federated fine-tuning of generative LLMs has gained attention as a way to leverage distributed data while preserving confidentiality. However, this setting introduces fundamental challenges: (i) privacy leakage of personally identifiable information (PII) due to LLM memorization, and (ii) a persistent tension between global generalization and local utility under heterogeneous data. Existing defenses, such as data sanitization and differential privacy, reduce leakage but often degrade downstream performance. We propose SecureGate, a privacy-aware federated fine-tuning framework for LLMs that provides fine-grained privacy control without sacrificing utility. SecureGate employs a dual-adapter LoRA architecture: a secure adapter that learns sanitized, globally shareable representations, and a revealing adapter that captures sensitive, organization-specific knowledge. A token-controlled gating module selectively activates these adapters at inference time, enabling controlled information disclosure without retraining. Extensive experiments across multiple LLMs and real-world datasets show that SecureGate improves task utility while substantially reducing PII leakage, achieving up to a 31.66X reduction in inference attack accuracy and a 17.07X reduction in extraction recall for unauthorized requests. Additionally, it maintains 100% routing reliability to the correct adapter and incurs only minimal computational and communication overhead.