A Flexible and Intelligent Framework for Remote Health Monitoring Dashboards

Developing and maintaining monitoring panels is undoubtedly the main task in the remote patient monitoring (RPM) systems. Due to the significant variations in desired functionalities, data sources, and objectives, designing an efficient dashboard that responds to the various needs in an RPM project is generally a cumbersome task to carry out. In this work, we present ViSierra, a framework for designing data monitoring dashboards in RPM projects. The abstractions and different components of this open-source project are explained, and examples are provided to support our claim concerning the effectiveness of this framework in preparing fast, efficient, and accurate monitoring platforms with minimal coding. These platforms will cover all the necessary aspects in a traditional RPM project and combine them with novel functionalities such as machine learning solutions and provide better data analysis instruments for the experts to track the information.

Hierarchical Target-Attentive Diagnosis Prediction in Heterogeneous Information Networks

We introduce HTAD, a novel model for diagnosis prediction using Electronic Health Records (EHR) represented as Heterogeneous Information Networks. Recent studies on modeling EHR have shown success in automatically learning representations of the clinical records in order to avoid the need for manual feature selection. However, these representations are often learned and aggregated without specificity for the different possible targets being predicted. Our model introduces a target-aware hierarchical attention mechanism that allows it to learn to attend to the most important clinical records when aggregating their representations for prediction of a diagnosis. We evaluate our model using a publicly available benchmark dataset and demonstrate that the use of target-aware attention significantly improves performance compared to the current state of the art. Additionally, we propose a method for incorporating non-categorical data into our predictions and demonstrate that this technique leads to further performance improvements. Lastly, we demonstrate that the predictions made by our proposed model are easily interpretable.

Group-Connected Multilayer Perceptron Networks

Despite the success of deep learning in domains such as image, voice, and graphs, there has been little progress in deep representation learning for domains without a known structure between features. For instance, a tabular dataset of different demographic and clinical factors where the feature interactions are not given as a prior. In this paper, we propose Group-Connected Multilayer Perceptron (GMLP) networks to enable deep representation learning in these domains. GMLP is based on the idea of learning expressive feature combinations (groups) and exploiting them to reduce the network complexity by defining local group-wise operations. During the training phase, GMLP learns a sparse feature grouping matrix using temperature annealing softmax with an added entropy loss term to encourage the sparsity. Furthermore, an architecture is suggested which resembles binary trees, where group-wise operations are followed by pooling operations to combine information; reducing the number of groups as the network grows in depth. To evaluate the proposed method, we conducted experiments on five different real-world datasets covering various application areas. Additionally, we provide visualizations on MNIST and synthesized data. According to the results, GMLP is able to successfully learn and exploit expressive feature combinations and achieve state-of-the-art classification performance on different datasets.

Cost-Sensitive Feature-Value Acquisition Using Feature Relevance

In many real-world machine learning problems, feature values are not readily available. To make predictions, some of the missing features have to be acquired, which can incur a cost in money, computational time, or human time, depending on the problem domain. This leads us to the problem of choosing which features to use at the prediction time. The chosen features should increase the prediction accuracy for a low cost, but determining which features will do that is challenging. The choice should take into account the previously acquired feature values as well as the feature costs. This paper proposes a novel approach to address this problem. The proposed approach chooses the most useful features adaptively based on how relevant they are for the prediction task as well as what the corresponding feature costs are. Our approach uses a generic neural network architecture, which is suitable for a wide range of problems. We evaluate our approach on three cost-sensitive datasets, including Yahoo! Learning to Rank Competition dataset as well as two health datasets. We show that our approach achieves high accuracy with a lower cost than the current state-of-the-art approaches.

Unsupervised Representation for EHR Signals and Codes as Patient Status Vector

Effective modeling of electronic health records presents many challenges as they contain large amounts of irregularity most of which are due to the varying procedures and diagnosis a patient may have. Despite the recent progress in machine learning, unsupervised learning remains largely at open, especially in the healthcare domain. In this work, we present a two-step unsupervised representation learning scheme to summarize the multi-modal clinical time series consisting of signals and medical codes into a patient status vector. First, an auto-encoder step is used to reduce sparse medical codes and clinical time series into a distributed representation. Subsequently, the concatenation of the distributed representations is further fine-tuned using a forecasting task. We evaluate the usefulness of the representation on two downstream tasks: mortality and readmission. Our proposed method shows improved generalization performance for both short duration ICU visits and long duration ICU visits.

Target-Focused Feature Selection Using a Bayesian Approach

In many real-world scenarios where data is high dimensional, test time acquisition of features is a non-trivial task due to costs associated with feature acquisition and evaluating feature value. The need for highly confident models with an extremely frugal acquisition of features can be addressed by allowing a feature selection method to become target aware. We introduce an approach to feature selection that is based on Bayesian learning, allowing us to report target-specific levels of uncertainty, false positive, and false negative rates. In addition, measuring uncertainty lifts the restriction on feature selection being target agnostic, allowing for feature acquisition based on a single target of focus out of many. We show that acquiring features for a specific target is at least as good as common linear feature selection approaches for small non-sparse datasets, and surpasses these when faced with real-world healthcare data that is larger in scale and in sparseness.

TAPER: Time-Aware Patient EHR Representation

Effective representation learning of electronic health records is a challenging task and is becoming more important as the availability of such data is becoming pervasive. The data contained in these records are irregular and contain multiple modalities such as notes, and medical codes. They are preempted by medical conditions the patient may have, and are typically jotted down by medical staff. Accompanying codes are notes containing valuable information about patients beyond the structured information contained in electronic health records. We use transformer networks and the recently proposed BERT language model to embed these data streams into a unified vector representation. The presented approach effectively encodes a patient's visit data into a single distributed representation, which can be used for downstream tasks. Our model demonstrates superior performance and generalization on mortality, readmission and length of stay tasks using the publicly available MIMIC-III ICU dataset.

Generative Imputation and Stochastic Prediction

In many machine learning applications, we are faced with incomplete datasets. In the literature, missing data imputation techniques have been mostly concerned with filling missing values. However, the existence of missing values is synonymous with uncertainties not only over the distribution of missing values but also over target class assignments that require careful consideration. The objectives of this paper are twofold. First, we proposed a method for generating imputations from the conditional distribution of missing values given observed values. Second, we use the generated samples to estimate the distribution of target assignments given incomplete data. In order to generate imputations, we train a simple and effective generator network to generate imputations that a discriminator network is tasked to distinguish. Following this, a predictor network is trained using imputed samples from the generator network to capture the classification uncertainties and make predictions accordingly. The proposed method is evaluated on CIFAR-10 image dataset as well as two real-world tabular classification datasets, under various missingness rates and structures. Our experimental results show the effectiveness of the proposed method in generating imputations, as well as providing estimates for the class uncertainties in a classification task when faced with missing values.