Explainable Autoencoder-Based Anomaly Detection in IEC 61850 GOOSE Networks

The IEC 61850 Generic Object-Oriented Substation Event (GOOSE) protocol plays a critical role in real-time protection and automation of digital substations, yet its lack of native security mechanisms can expose power systems to sophisticated cyberattacks. Traditional rule-based and supervised intrusion detection techniques struggle to detect protocol-compliant and zero-day attacks under significant class imbalance and limited availability of labeled data. This paper proposes an explainable, unsupervised multi-view anomaly detection framework for IEC 61850 GOOSE networks that explicitly separates semantic integrity and temporal availability. The approach employs asymmetric autoencoders trained only on real operational GOOSE traffic to learn distinct latent representations of sequence-based protocol semantics and timing-related transmission dynamics in normal traffic. Anomaly detection is implemented using reconstruction errors mixed with statistically grounded thresholds, enabling robust detection without specified attack types. Feature-level reconstruction analysis provides intrinsic explainability by directly linking detection outcomes to IEC 61850 protocol characteristics. The proposed framework is evaluated using real substation traffic for training and a public dataset containing normal traffic and message suppression, data manipulation, and denial-of-service attacks for testing. Experimental results show attack detection rates above 99% with false positives remaining below 5% of total traffic, demonstrating strong generalization across environments and effective operation under extreme class imbalance and interpretable anomaly attribution.

Multivariate Feature Selection and Autoencoder Embeddings of Ovarian Cancer Clinical and Genetic Data

This study explores a data-driven approach to discovering novel clinical and genetic markers in ovarian cancer (OC). Two main analyses were performed: (1) a nonlinear examination of an OC dataset using autoencoders, which compress data into a 3-dimensional latent space to detect potential intrinsic separability between platinum-sensitive and platinum-resistant groups; and (2) an adaptation of the informative variable identifier (IVI) to determine which features (clinical or genetic) are most relevant to disease progression. In the autoencoder analysis, a clearer pattern emerged when using clinical features and the combination of clinical and genetic data, indicating that disease progression groups can be distinguished more effectively after supervised fine tuning. For genetic data alone, this separability was less apparent but became more pronounced with a supervised approach. Using the IVI-based feature selection, key clinical variables (such as type of surgery and neoadjuvant chemotherapy) and certain gene mutations showed strong relevance, along with low-risk genetic factors. These findings highlight the strength of combining machine learning tools (autoencoders) with feature selection methods (IVI) to gain insights into ovarian cancer progression. They also underscore the potential for identifying new biomarkers that integrate clinical and genomic indicators, ultimately contributing to improved patient stratification and personalized treatment strategies.