Deep Learning-Based BMD Estimation from Radiographs with Conformal Uncertainty Quantification

Limited DXA access hinders osteoporosis screening. This proof-of-concept study proposes using widely available knee X-rays for opportunistic Bone Mineral Density (BMD) estimation via deep learning, emphasizing robust uncertainty quantification essential for clinical use. An EfficientNet model was trained on the OAI dataset to predict BMD from bilateral knee radiographs. Two Test-Time Augmentation (TTA) methods were compared: traditional averaging and a multi-sample approach. Crucially, Split Conformal Prediction was implemented to provide statistically rigorous, patient-specific prediction intervals with guaranteed coverage. Results showed a Pearson correlation of 0.68 (traditional TTA). While traditional TTA yielded better point predictions, the multi-sample approach produced slightly tighter confidence intervals (90%, 95%, 99%) while maintaining coverage. The framework appropriately expressed higher uncertainty for challenging cases. Although anatomical mismatch between knee X-rays and standard DXA limits immediate clinical use, this method establishes a foundation for trustworthy AI-assisted BMD screening using routine radiographs, potentially improving early osteoporosis detection.

Risk-Sensitive Conformal Prediction for Catheter Placement Detection in Chest X-rays

This paper presents a novel approach to catheter and line position detection in chest X-rays, combining multi-task learning with risk-sensitive conformal prediction to address critical clinical requirements. Our model simultaneously performs classification, segmentation, and landmark detection, leveraging the synergistic relationship between these tasks to improve overall performance. We further enhance clinical reliability through risk-sensitive conformal prediction, which provides statistically guaranteed prediction sets with higher reliability for clinically critical findings. Experimental results demonstrate excellent performance with 90.68\% overall empirical coverage and 99.29\% coverage for critical conditions, while maintaining remarkable precision in prediction sets. Most importantly, our risk-sensitive approach achieves zero high-risk mispredictions (cases where the system dangerously declares problematic tubes as confidently normal), making the system particularly suitable for clinical deployment. This work offers both accurate predictions and reliably quantified uncertainty -- essential features for life-critical medical applications.