Multi-modal Integration Analysis of Alzheimer's Disease Using Large Language Models and Knowledge Graphs

We propose a novel framework for integrating fragmented multi-modal data in Alzheimer's disease (AD) research using large language models (LLMs) and knowledge graphs. While traditional multimodal analysis requires matched patient IDs across datasets, our approach demonstrates population-level integration of MRI, gene expression, biomarkers, EEG, and clinical indicators from independent cohorts. Statistical analysis identified significant features in each modality, which were connected as nodes in a knowledge graph. LLMs then analyzed the graph to extract potential correlations and generate hypotheses in natural language. This approach revealed several novel relationships, including a potential pathway linking metabolic risk factors to tau protein abnormalities via neuroinflammation (r>0.6, p<0.001), and unexpected correlations between frontal EEG channels and specific gene expression profiles (r=0.42-0.58, p<0.01). Cross-validation with independent datasets confirmed the robustness of major findings, with consistent effect sizes across cohorts (variance <15%). The reproducibility of these findings was further supported by expert review (Cohen's k=0.82) and computational validation. Our framework enables cross modal integration at a conceptual level without requiring patient ID matching, offering new possibilities for understanding AD pathology through fragmented data reuse and generating testable hypotheses for future research.

Optimal Fuzzy Model Construction with Statistical Information using Genetic Algorithm

Fuzzy rule based models have a capability to approximate any continuous function to any degree of accuracy on a compact domain. The majority of FLC design process relies on heuristic knowledge of experience operators. In order to make the design process automatic we present a genetic approach to learn fuzzy rules as well as membership function parameters. Moreover, several statistical information criteria such as the Akaike information criterion (AIC), the Bhansali-Downham information criterion (BDIC), and the Schwarz-Rissanen information criterion (SRIC) are used to construct optimal fuzzy models by reducing fuzzy rules. A genetic scheme is used to design Takagi-Sugeno-Kang (TSK) model for identification of the antecedent rule parameters and the identification of the consequent parameters. Computer simulations are presented confirming the performance of the constructed fuzzy logic controller.