Mix, Align, Distil: Reliable Cross-Domain Atypical Mitosis Classification

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple training-time recipe for domain-robust AMF classification in MIDOG 2025 Task 2. The approach (i) increases feature diversity via style perturbations inserted at early and mid backbone stages, (ii) aligns attention-refined features across sites using weak domain labels (Scanner, Origin, Species, Tumor) through an auxiliary alignment loss, and (iii) stabilizes predictions by distilling from an exponential moving average (EMA) teacher with temperature-scaled KL divergence. On the organizer-run preliminary leaderboard for atypical mitosis classification, our submission attains balanced accuracy of 0.8762, sensitivity of 0.8873, specificity of 0.8651, and ROC AUC of 0.9499. The method incurs negligible inference-time overhead, relies only on coarse domain metadata, and delivers strong, balanced performance, positioning it as a competitive submission for the MIDOG 2025 challenge.

On the modern deep learning approaches for precipitation downscaling

Deep Learning (DL) based downscaling has become a popular tool in earth sciences recently. Increasingly, different DL approaches are being adopted to downscale coarser precipitation data and generate more accurate and reliable estimates at local (~few km or even smaller) scales. Despite several studies adopting dynamical or statistical downscaling of precipitation, the accuracy is limited by the availability of ground truth. A key challenge to gauge the accuracy of such methods is to compare the downscaled data to point-scale observations which are often unavailable at such small scales. In this work, we carry out the DL-based downscaling to estimate the local precipitation data from the India Meteorological Department (IMD), which was created by approximating the value from station location to a grid point. To test the efficacy of different DL approaches, we apply four different methods of downscaling and evaluate their performance. The considered approaches are (i) Deep Statistical Downscaling (DeepSD), augmented Convolutional Long Short Term Memory (ConvLSTM), fully convolutional network (U-NET), and Super-Resolution Generative Adversarial Network (SR-GAN). A custom VGG network, used in the SR-GAN, is developed in this work using precipitation data. The results indicate that SR-GAN is the best method for precipitation data downscaling. The downscaled data is validated with precipitation values at IMD station. This DL method offers a promising alternative to statistical downscaling.