The method of direct imaging has detected many exoplanets and made important contribution to the field of planet formation. The standard method employs angular differential imaging (ADI) technique, and more ADI image frames could lead to the results with larger signal-to-noise-ratio (SNR). However, it would need precious observational time from large telescopes, which are always over-subscribed. We thus explore the possibility to generate a converter which can increase the SNR derived from a smaller number of ADI frames. The machine learning technique with two-dimension convolutional neural network (2D-CNN) is tested here. Several 2D-CNN models are trained and their performances of denoising are presented and compared. It is found that our proposed Modified five-layer Wide Inference Network with the Residual learning technique and Batch normalization (MWIN5-RB) can give the best result. We conclude that this MWIN5-RB can be employed as a converter for future observational data.
X-ray examination is suitable for screening of gastric cancer. Compared to endoscopy, which can only be performed by doctors, X-ray imaging can also be performed by radiographers, and thus, can treat more patients. However, the diagnostic accuracy of gastric radiographs is as low as 85%. To address this problem, highly accurate and quantitative automated diagnosis using machine learning needs to be performed. This paper proposes a diagnostic support method for detecting gastric cancer sites from X-ray images with high accuracy. The two new technical proposal of the method are (1) stochastic functional gastric image augmentation (sfGAIA), and (2) hard boundary box training (HBBT). The former is a probabilistic enhancement of gastric folds in X-ray images based on medical knowledge, whereas the latter is a recursive retraining technique to reduce false positives. We use 4,724 gastric radiographs of 145 patients in clinical practice and evaluate the cancer detection performance of the method in a patient-based five-group cross-validation. The proposed sfGAIA and HBBT significantly enhance the performance of the EfficientDet-D7 network by 5.9% in terms of the F1-score, and our screening method reaches a practical screening capability for gastric cancer (F1: 57.8%, recall: 90.2%, precision: 42.5%).