Projected multi-reference alignment

Motivated by structural biology applications, we study the projected multi-reference alignment (MRA) model, in which an unknown signal is observed through noisy samples, each generated by applying a random cyclic shift followed by a fixed projection. The projection merges reflection-symmetric index pairs, thereby discarding orientation information. The goal is to recover the dihedral orbit of the signal. We prove that in the high-noise regime, the first three moments of the projected observations determine a generic dihedral orbit. The main mechanism is a reduction, at the moment level, from projected MRA to the reflection-invariant phase-coupling structure of dihedral MRA. In Fourier-cosine coordinates adapted to the projection, the first moment determines the mean component, the second moment determines the Fourier magnitudes, and selected third moments yield the cosine phase-coupling relations appearing in the dihedral bispectrum. These relations lead to a constructive recovery scheme from moments up to order three. We complement the population theory with finite-sample experiments comparing expectation--maximization (EM), direct moment optimization, and direct Fourier-cosine moment optimization. The results show that, in the high-noise regime, both EM and direct moment optimization are consistent with the predicted third-moment sample-complexity scaling $n \gtrsim σ^6$, where $n$ is the number of observations and $σ^2$ is the noise variance.

Provable orbit recovery over SO(3) from the non-uniform second moment

We study the recovery of an unknown three-dimensional band-limited signal from multiple noisy observations that are randomly rotated by latent elements of SO(3), where the rotations are drawn from an unknown, non-uniform distribution. Because the rotations are unobserved, only the signal orbit under the rotation group can be recovered. We show that the signal orbit and the rotation distribution are jointly identifiable from the first and second moments. This yields an improved high-noise sample complexity that scales quadratically with the noise variance, rather than cubically as in the uniform-rotation case. We further develop a provable, computationally efficient reconstruction algorithm that recovers the 3-D signal by successively solving a sequence of well-conditioned linear systems. The algorithm is validated through extensive numerical experiments. Our results provide a principled and tractable framework for high-noise 3-D orbit recovery, with potential relevance to cryo-electron microscopy and cryo-electron tomography modeling, where molecules are observed in unknown orientations.