Inferring the timing and amplitude of perturbations in epidemiological systems from their stochastically spread low-resolution outcomes is as relevant as challenging. It is a requirement for current approaches to overcome the need to know the details of the perturbations to proceed with the analyses. However, the general problem of connecting epidemiological curves with the underlying incidence lacks the highly effective methodology present in other inverse problems, such as super-resolution and dehazing from computer vision. Here, we develop an unsupervised physics-informed convolutional neural network approach in reverse to connect death records with incidence that allows the identification of regime changes at single-day resolution. Applied to COVID-19 data with proper regularization and model-selection criteria, the approach can identify the implementation and removal of lockdowns and other nonpharmaceutical interventions with 0.93-day accuracy over the time span of a year.
This paper provides a description of the approach and methodology I used in winning the European Union Big Data Technologies Horizon Prize on data-driven prediction of electricity grid traffic. The methodology relies on identifying typical short-term recurrent fluctuations, which is subsequently refined through a regression-of-fluctuations approach. The key points and strategic considerations that led to selecting or discarding different methodological aspects are also discussed. The criteria include adaptability to changing conditions, reliability with outliers and missing data, robustness to noise, and efficiency in implementation.