DA-SSL: self-supervised domain adaptor to leverage foundational models in turbt histopathology slides

Recent deep learning frameworks in histopathology, particularly multiple instance learning (MIL) combined with pathology foundational models (PFMs), have shown strong performance. However, PFMs exhibit limitations on certain cancer or specimen types due to domain shifts - these cancer types were rarely used for pretraining or specimens contain tissue-based artifacts rarely seen within the pretraining population. Such is the case for transurethral resection of bladder tumor (TURBT), which are essential for diagnosing muscle-invasive bladder cancer (MIBC), but contain fragmented tissue chips and electrocautery artifacts and were not widely used in publicly available PFMs. To address this, we propose a simple yet effective domain-adaptive self-supervised adaptor (DA-SSL) that realigns pretrained PFM features to the TURBT domain without fine-tuning the foundational model itself. We pilot this framework for predicting treatment response in TURBT, where histomorphological features are currently underutilized and identifying patients who will benefit from neoadjuvant chemotherapy (NAC) is challenging. In our multi-center study, DA-SSL achieved an AUC of 0.77+/-0.04 in five-fold cross-validation and an external test accuracy of 0.84, sensitivity of 0.71, and specificity of 0.91 using majority voting. Our results demonstrate that lightweight domain adaptation with self-supervision can effectively enhance PFM-based MIL pipelines for clinically challenging histopathology tasks. Code is Available at https://github.com/zhanghaoyue/DA_SSL_TURBT.

Evaluating Speech-to-Text Systems with PennSound

A random sample of nearly 10 hours of speech from PennSound, the world's largest online collection of poetry readings and discussions, was used as a benchmark to evaluate several commercial and open-source speech-to-text systems. PennSound's wide variation in recording conditions and speech styles makes it a good representative for many other untranscribed audio collections. Reference transcripts were created by trained annotators, and system transcripts were produced from AWS, Azure, Google, IBM, NeMo, Rev.ai, Whisper, and Whisper.cpp. Based on word error rate, Rev.ai was the top performer, and Whisper was the top open source performer (as long as hallucinations were avoided). AWS had the best diarization error rates among three systems. However, WER and DER differences were slim, and various tradeoffs may motivate choosing different systems for different end users. We also examine the issue of hallucinations in Whisper. Users of Whisper should be cautioned to be aware of runtime options, and whether the speed vs accuracy trade off is acceptable.