Sherpa.ai Privacy-Preserving Multi-Party Entity Alignment without Intersection Disclosure for Noisy Identifiers

Federated Learning (FL) enables collaborative model training among multiple parties without centralizing raw data. There are two main paradigms in FL: Horizontal FL (HFL), where all participants share the same feature space but hold different samples, and Vertical FL (VFL), where parties possess complementary features for the same set of samples. A prerequisite for VFL training is privacy-preserving entity alignment (PPEA), which establishes a common index of samples across parties (alignment) without revealing which samples are shared between them. Conventional private set intersection (PSI) achieves alignment but leaks intersection membership, exposing sensitive relationships between datasets. The standard private set union (PSU) mitigates this risk by aligning on the union of identifiers rather than the intersection. However, existing approaches are often limited to two parties or lack support for typo-tolerant matching. In this paper, we introduce the Sherpa.ai multi-party PSU protocol for VFL, a PPEA method that hides intersection membership and enables both exact and noisy matching. The protocol generalizes two-party approaches to multiple parties with low communication overhead and offers two variants: an order-preserving version for exact alignment and an unordered version tolerant to typographical and formatting discrepancies. We prove correctness and privacy, analyze communication and computational (exponentiation) complexity, and formalize a universal index mapping from local records to a shared index space. This multi-party PSU offers a scalable, mathematically grounded protocol for PPEA in real-world VFL deployments, such as multi-institutional healthcare disease detection, collaborative risk modeling between banks and insurers, and cross-domain fraud detection between telecommunications and financial institutions, while preserving intersection privacy.

Federated Learning for Pediatric Pneumonia Detection: Enabling Collaborative Diagnosis Without Sharing Patient Data

Early and accurate pneumonia detection from chest X-rays (CXRs) is clinically critical to expedite treatment and isolation, reduce complications, and curb unnecessary antibiotic use. Although artificial intelligence (AI) substantially improves CXR-based detection, development is hindered by globally distributed data, high inter-hospital variability, and strict privacy regulations (e.g., HIPAA, GDPR) that make centralization impractical. These constraints are compounded by heterogeneous imaging protocols, uneven data availability, and the costs of transferring large medical images across geographically dispersed sites. In this paper, we evaluate Federated Learning (FL) using the Sherpa.ai FL platform, enabling multiple hospitals (nodes) to collaboratively train a CXR classifier for pneumonia while keeping data in place and private. Using the Pediatric Pneumonia Chest X-ray dataset, we simulate cross-hospital collaboration with non-independent and non-identically distributed (non-IID) data, reproducing real-world variability across institutions and jurisdictions. Our experiments demonstrate that collaborative and privacy-preserving training across multiple hospitals via FL led to a dramatic performance improvement achieving 0.900 Accuracy and 0.966 ROC-AUC, corresponding to 47.5% and 50.0% gains over single-hospital models (0.610; 0.644), without transferring any patient CXR. These results indicate that FL delivers high-performing, generalizable, secure and private pneumonia detection across healthcare networks, with data kept local. This is especially relevant for rare diseases, where FL enables secure multi-institutional collaboration without data movement, representing a breakthrough for accelerating diagnosis and treatment development in low-data domains.