MEIcoder: Decoding Visual Stimuli from Neural Activity by Leveraging Most Exciting Inputs

Decoding visual stimuli from neural population activity is crucial for understanding the brain and for applications in brain-machine interfaces. However, such biological data is often scarce, particularly in primates or humans, where high-throughput recording techniques, such as two-photon imaging, remain challenging or impossible to apply. This, in turn, poses a challenge for deep learning decoding techniques. To overcome this, we introduce MEIcoder, a biologically informed decoding method that leverages neuron-specific most exciting inputs (MEIs), a structural similarity index measure loss, and adversarial training. MEIcoder achieves state-of-the-art performance in reconstructing visual stimuli from single-cell activity in primary visual cortex (V1), especially excelling on small datasets with fewer recorded neurons. Using ablation studies, we demonstrate that MEIs are the main drivers of the performance, and in scaling experiments, we show that MEIcoder can reconstruct high-fidelity natural-looking images from as few as 1,000-2,500 neurons and less than 1,000 training data points. We also propose a unified benchmark with over 160,000 samples to foster future research. Our results demonstrate the feasibility of reliable decoding in early visual system and provide practical insights for neuroscience and neuroengineering applications.

Investigation into the Training Dynamics of Learned Optimizers

Optimization is an integral part of modern deep learning. Recently, the concept of learned optimizers has emerged as a way to accelerate this optimization process by replacing traditional, hand-crafted algorithms with meta-learned functions. Despite the initial promising results of these methods, issues with stability and generalization still remain, limiting their practical use. Moreover, their inner workings and behavior under different conditions are not yet fully understood, making it difficult to come up with improvements. For this reason, our work examines their optimization trajectories from the perspective of network architecture symmetries and parameter update distributions. Furthermore, by contrasting the learned optimizers with their manually designed counterparts, we identify several key insights that demonstrate how each approach can benefit from the strengths of the other.