Abstract:Backpropagation is the cornerstone of deep learning, but its reliance on symmetric weight transport and global synchronization makes it computationally expensive and biologically implausible. Feedback alignment offers a promising alternative by approximating error gradients through fixed random feedback, thereby avoiding symmetric weight transport. However, this approach often struggles with poor learning performance and instability, especially in deep networks. Here, we show that a one-time soft alignment between forward and feedback weights at initialization enables deep networks to achieve performance comparable to backpropagation, without requiring weight transport during learning. This simple initialization condition guides stable error minimization in the loss landscape, improving network trainability. Spectral analyses further reveal that initial alignment promotes smoother gradient flow and convergence to flatter minima, resulting in better generalization and robustness. Notably, we also find that allowing moderate deviations from exact weight symmetry can improve adversarial robustness compared to standard backpropagation. These findings demonstrate that a simple initialization strategy can enable effective learning in deep networks in a biologically plausible and resource-efficient manner.