Hybrid Quantum Neural Network for Multivariate Clinical Time Series Forecasting

Forecasting physiological signals can support proactive monitoring and timely clinical intervention by anticipating critical changes in patient status. In this work, we address multivariate multi-horizon forecasting of physiological time series by jointly predicting heart rate, oxygen saturation, pulse rate, and respiratory rate at forecasting horizons of 15, 30, and 60 seconds. We propose a hybrid quantum-classical architecture that integrates a Variational Quantum Circuit (VQC) within a recurrent neural backbone. A GRU encoder summarizes the historical observation window into a latent representation, which is then projected into quantum angles used to parameterize the VQC. The quantum layer acts as a learnable non-linear feature mixer, modeling cross-variable interactions before the final prediction stage. We evaluate the proposed approach on the BIDMC PPG and Respiration dataset under a Leave-One-Patient-Out protocol. The results show competitive accuracy compared with classical and deep learning baselines, together with greater robustness to noise and missing inputs. These findings suggest that hybrid quantum layers can provide useful inductive biases for physiological time series forecasting in small-cohort clinical settings.

Sample-Aware Test-Time Adaptation for Medical Image-to-Image Translation

Image-to-image translation has emerged as a powerful technique in medical imaging, enabling tasks such as image denoising and cross-modality conversion. However, it suffers from limitations in handling out-of-distribution samples without causing performance degradation. To address this limitation, we propose a novel Test-Time Adaptation (TTA) framework that dynamically adjusts the translation process based on the characteristics of each test sample. Our method introduces a Reconstruction Module to quantify the domain shift and a Dynamic Adaptation Block that selectively modifies the internal features of a pretrained translation model to mitigate the shift without compromising the performance on in-distribution samples that do not require adaptation. We evaluate our approach on two medical image-to-image translation tasks: low-dose CT denoising and T1 to T2 MRI translation, showing consistent improvements over both the baseline translation model without TTA and prior TTA methods. Our analysis highlights the limitations of the state-of-the-art that uniformly apply the adaptation to both out-of-distribution and in-distribution samples, demonstrating that dynamic, sample-specific adjustment offers a promising path to improve model resilience in real-world scenarios. The code is available at: https://github.com/cosbidev/Sample-Aware_TTA.