Latent-Kernel Discrete Flow Maps for Few-Step Generation

Discrete diffusion and flow-matching models denoise a sequence over many steps, but to keep each step cheap, they factorize the transition across positions and decide every token independently. This makes few-step generation challenging for text when the target couples two positions, such as a subject and a verb that must agree. An independent update commits to them separately, and many function evaluations are spent repairing the mismatch. Existing few-step methods buy back the lost correlation by distilling or rectifying a slow teacher, and so inherit the teacher's quality ceiling. We ask instead whether a model can express correlated steps natively, and answer with Latent-Kernel Discrete Flow Maps (LKF), a from-scratch flow-map kernel that is a mixture of M factorized components tied by a single shared latent. Conditioned on the latent, each component is cheap, and the mixture is summed over the latent in closed form for small M. We show that a single step places mass on correlated completions with the same sampling time complexity as a factorized model, since one latent is drawn per sequence and reused across the entire denoising trajectory. We also show that the Masked Diffusion Language Model (MDLM) is a special case of our LKF model at M=1. The experiments for unconditional text generation on the One-Billion-Word (LM1B) and WikiText-103 benchmarks show that our LKF model learns strongly heterogeneous components and improves generative perplexity by 2.1x to 3.3x over the likelihood baselines without losing diversity. The gain grows with M, and at M=8, it surpasses distilled and rectified few-step samplers. The source code is available at: https://github.com/mansoor181/lkf.git

EpiFormer: Learning Antigen-Antibody Interactions for Epitope Prediction via Geometric Deep Learning

Antibodies neutralize foreign antigens by binding to specific surface regions called epitopes. Computational epitope prediction is critical for understanding immune recognition and guiding antibody engineering. However, existing methods face three fundamental challenges: antibody-aware models encode each chain independently and combine them only at a late stage, failing to capture co-dependent structural features that define binding interfaces, whereas severe class imbalance and scarcity of known antibody-antigen complexes render standard training objectives ineffective. We propose EpiFormer, a general encoder-decoder framework that addresses these challenges jointly. Our key design principle is interleaved cross-attention within GNN encoding layers, enabling bidirectional antigen-antibody information flow throughout representation learning rather than only at the output. This early-fusion principle is backbone-agnostic, providing consistent gains across GNN architectures from simple GCNs to equivariant models. We further show that sparsity-aware objectives are effective when paired with early-fusion architectures for the epitope prediction task. EpiFormer improves over the previous best method by over 40% in F1 score on standard benchmarks, demonstrating generalizability and cross-dataset transferability. Notably, EpiFormer discovers known biological principles as emergent behaviors of end-to-end training, where the learned cross-attention gates favor antigen-to-antibody information flow, consistent with the asymmetric roles of the two chains at the binding interface, and the model's preference for geometric over evolutionary features aligns with the established finding that epitope residues are not evolutionarily conserved. The source code is available at: https://github.com/mansoor181/epiformer.git

CHIMERA-Bench: A Benchmark Dataset for Epitope-Specific Antibody Design

Computational antibody design has seen rapid methodological progress, with dozens of deep generative methods proposed in the past three years, yet the field lacks a standardized benchmark for fair comparison and model development. These methods are evaluated on different SAbDab snapshots, non-overlapping test sets, and incompatible metrics, and the literature fragments the design problem into numerous sub-tasks with no common definition. We introduce \textsc{Chimera-Bench} (\textbf{C}DR \textbf{M}odeling with \textbf{E}pitope-guided \textbf{R}edesign), a unified benchmark built around a single canonical task: \emph{epitope-conditioned CDR sequence-structure co-design}. \textsc{Chimera-Bench} provides (1) a curated, deduplicated dataset of \textbf{2,922} antibody-antigen complexes with epitope and paratope annotations; (2) three biologically motivated splits testing generalization to unseen epitopes, unseen antigen folds, and prospective temporal targets; and (3) a comprehensive evaluation protocol with five metric groups including novel epitope-specificity measures. We benchmark representative methods spanning different generative paradigms and report results across all splits. \textsc{Chimera-Bench} is the largest dataset of its kind for the antibody design problem, allowing the community to develop and test novel methods and evaluate their generalizability. The source code and data are available at: https://github.com/mansoor181/chimera-bench.git

Dataset Augmentation by Mixing Visual Concepts

This paper proposes a dataset augmentation method by fine-tuning pre-trained diffusion models. Generating images using a pre-trained diffusion model with textual conditioning often results in domain discrepancy between real data and generated images. We propose a fine-tuning approach where we adapt the diffusion model by conditioning it with real images and novel text embeddings. We introduce a unique procedure called Mixing Visual Concepts (MVC) where we create novel text embeddings from image captions. The MVC enables us to generate multiple images which are diverse and yet similar to the real data enabling us to perform effective dataset augmentation. We perform comprehensive qualitative and quantitative evaluations with the proposed dataset augmentation approach showcasing both coarse-grained and finegrained changes in generated images. Our approach outperforms state-of-the-art augmentation techniques on benchmark classification tasks.

Domain Adaptation Using Pseudo Labels

In the absence of labeled target data, unsupervised domain adaptation approaches seek to align the marginal distributions of the source and target domains in order to train a classifier for the target. Unsupervised domain alignment procedures are category-agnostic and end up misaligning the categories. We address this problem by deploying a pretrained network to determine accurate labels for the target domain using a multi-stage pseudo-label refinement procedure. The filters are based on the confidence, distance (conformity), and consistency of the pseudo labels. Our results on multiple datasets demonstrate the effectiveness of our simple procedure in comparison with complex state-of-the-art techniques.

Domain-Invariant Feature Alignment Using Variational Inference For Partial Domain Adaptation

The standard closed-set domain adaptation approaches seek to mitigate distribution discrepancies between two domains under the constraint of both sharing identical label sets. However, in realistic scenarios, finding an optimal source domain with identical label space is a challenging task. Partial domain adaptation alleviates this problem of procuring a labeled dataset with identical label space assumptions and addresses a more practical scenario where the source label set subsumes the target label set. This, however, presents a few additional obstacles during adaptation. Samples with categories private to the source domain thwart relevant knowledge transfer and degrade model performance. In this work, we try to address these issues by coupling variational information and adversarial learning with a pseudo-labeling technique to enforce class distribution alignment and minimize the transfer of superfluous information from the source samples. The experimental findings in numerous cross-domain classification tasks demonstrate that the proposed technique delivers superior and comparable accuracy to existing methods.

PatchRot: A Self-Supervised Technique for Training Vision Transformers

Vision transformers require a huge amount of labeled data to outperform convolutional neural networks. However, labeling a huge dataset is a very expensive process. Self-supervised learning techniques alleviate this problem by learning features similar to supervised learning in an unsupervised way. In this paper, we propose a self-supervised technique PatchRot that is crafted for vision transformers. PatchRot rotates images and image patches and trains the network to predict the rotation angles. The network learns to extract both global and local features from an image. Our extensive experiments on different datasets showcase PatchRot training learns rich features which outperform supervised learning and compared baseline.

Coupling Adversarial Learning with Selective Voting Strategy for Distribution Alignment in Partial Domain Adaptation

In contrast to a standard closed-set domain adaptation task, partial domain adaptation setup caters to a realistic scenario by relaxing the identical label set assumption. The fact of source label set subsuming the target label set, however, introduces few additional obstacles as training on private source category samples thwart relevant knowledge transfer and mislead the classification process. To mitigate these issues, we devise a mechanism for strategic selection of highly-confident target samples essential for the estimation of class-importance weights. Furthermore, we capture class-discriminative and domain-invariant features by coupling the process of achieving compact and distinct class distributions with an adversarial objective. Experimental findings over numerous cross-domain classification tasks demonstrate the potential of the proposed technique to deliver superior and comparable accuracy over existing methods.

Sparsity Regularization For Cold-Start Recommendation

Recently, Generative Adversarial Networks (GANs) have been applied to the problem of Cold-Start Recommendation, but the training performance of these models is hampered by the extreme sparsity in warm user purchase behavior. In this paper we introduce a novel representation for user-vectors by combining user demographics and user preferences, making the model a hybrid system which uses Collaborative Filtering and Content Based Recommendation. Our system models user purchase behavior using weighted user-product preferences (explicit feedback) rather than binary user-product interactions (implicit feedback). Using this we develop a novel sparse adversarial model, SRLGAN, for Cold-Start Recommendation leveraging the sparse user-purchase behavior which ensures training stability and avoids over-fitting on warm users. We evaluate the SRLGAN on two popular datasets and demonstrate state-of-the-art results.

Partial Domain Adaptation Using Selective Representation Learning For Class-Weight Computation

The generalization power of deep-learning models is dependent on rich-labelled data. This supervision using large-scaled annotated information is restrictive in most real-world scenarios where data collection and their annotation involve huge cost. Various domain adaptation techniques exist in literature that bridge this distribution discrepancy. However, a majority of these models require the label sets of both the domains to be identical. To tackle a more practical and challenging scenario, we formulate the problem statement from a partial domain adaptation perspective, where the source label set is a super set of the target label set. Driven by the motivation that image styles are private to each domain, in this work, we develop a method that identifies outlier classes exclusively from image content information and train a label classifier exclusively on class-content from source images. Additionally, elimination of negative transfer of samples from classes private to the source domain is achieved by transforming the soft class-level weights into two clusters, 0 (outlier source classes) and 1 (shared classes) by maximizing the between-cluster variance between them.