DexDirect: Direct Kinesthetic Arm Guidance for Efficient Dexterous Demonstration Collection

Scalable collection of dexterous manipulation demonstrations remains a major bottleneck for robot learning. High-fidelity interfaces often require costly hardware and extensive setup, while low-setup, low cost alternatives tend to provide less precise control and impose greater cognitive workload on operators. We present DexDirect, a direct kinesthetic arm guidance for efficient dexterous demonstration collection. The operator drags a 6-DoF gravity-compensated robot arm directly by a handle, while a single webcam retargets operator's other hand onto a 16 joints 13-DoF dexterous robot hand. User studies suggest DexDirect collects 17.2x and 3.2x more successful demonstrations compared to purely vision (AnyTeleop) and pose-tracking (TeleDex) baselines. An adapted NASA-TLX shows DexDirect greatly reduces mental demand, effort, and frustration, despite raising physical demand. A diffusion policy trained on DexDirect demonstrations reaches a 90% success rate on a cube pick-and-place task. These results suggest that direct kinesthetic arm guidance combined with vision-based hand retargeting provides an efficient low-setup and scalable interface for collecting dexterous manipulation demonstrations

RAVEN: Reinforcement-Adaptive Visibility-Graph Planning for Robust Humanoid Navigation with Collision-Free MPC

Humanoid navigation in dynamic environments requires long-horizon planning while respecting short-horizon dynamic and safety constraints. Classical visibility-graph planners combined with model predictive control (MPC) can efficiently generate collision-free trajectories, but their performance depends on manually tuned parameters and accurate system modeling. In real robotic systems, control delays, state-estimation noise, and locomotion uncertainties can cause overshoot and constraint violations even when the nominal path is geometrically optimal. We propose RAVEN, a hierarchical reinforcement learning (RL)-MPC framework for robust humanoid navigation. Unlike prior approaches that use learning to tune cost weights or replace planning entirely, RAVEN employs RL to adapt the geometric construction of a visibility-graph planner by modifying obstacle inflation and related graph parameters. By directly reshaping the free-space geometry, the learned planner alters the topology of the global path to compensate for delay and tracking imperfections. A collision-free MPC layer then tracks the planned trajectory while explicitly enforcing velocity bounds and obstacle-avoidance constraints. By training under realistic delays and observation noise, RAVEN learns planning adaptations that improve robustness while retaining explicit long-horizon geometric planning and constrained optimization, in contrast to end-to-end learning approaches. We evaluate RAVEN against a manually tuned visibility-graph MPC baseline and a pure RL navigation policy. Results demonstrate reduced overshoot near obstacles, improved robustness in narrow passages, and more reliable navigation under delay and noise. These findings indicate that reinforcement-adaptive graph construction combined with constrained MPC provides an effective and interpretable alternative to end-to-end learning for robust humanoid navigation.

DexEXO: A Wearability-First Dexterous Exoskeleton for Operator-Agnostic Demonstration and Learning

Scaling dexterous robot learning is constrained by the difficulty of collecting high-quality demonstrations across diverse operators. Existing wearable interfaces often trade comfort and cross-user adaptability for kinematic fidelity, while embodiment mismatch between demonstration and deployment requires visual post-processing before policy training. We present DexEXO, a wearability-first hand exoskeleton that aligns visual appearance, contact geometry, and kinematics at the hardware level. DexEXO features a pose-tolerant thumb mechanism and a slider-based finger interface analytically modeled to support hand lengths from 140~mm to 217~mm, reducing operator-specific fitting and enabling scalable cross-operator data collection. A passive hand visually matches the deployed robot, allowing direct policy training from raw wrist-mounted RGB observations. User studies demonstrate improved comfort and usability compared to prior wearable systems. Using visually aligned observations alone, we train diffusion policies that achieve competitive performance while substantially simplifying the end-to-end pipeline. These results show that prioritizing wearability and hardware-level embodiment alignment reduces both human and algorithmic bottlenecks without sacrificing task performance. Project Page: https://dexexo-research.github.io/

Bidirectional Mamba for Single-Cell Data: Efficient Context Learning with Biological Fidelity

Single-cell RNA sequencing (scRNA-seq) enables high-resolution analysis of cellular heterogeneity, but its complexity, which is marked by high dimensionality, sparsity, and batch effects, which poses major computational challenges. Transformer-based models have made significant advances in this domain but are often limited by their quadratic complexity and suboptimal handling of long-range dependencies. In this work, we introduce GeneMamba, a scalable and efficient foundation model for single-cell transcriptomics built on state space modeling. Leveraging the Bi-Mamba architecture, GeneMamba captures bidirectional gene context with linear-time complexity, offering substantial computational gains over transformer baselines. The model is pretrained on nearly 30 million cells and incorporates biologically informed objectives, including pathway-aware contrastive loss and rank-based gene encoding. We evaluate GeneMamba across diverse tasks, including multi-batch integration, cell type annotation, and gene-gene correlation, demonstrating strong performance, interpretability, and robustness. These results position GeneMamba as a practical and powerful alternative to transformer-based methods, advancing the development of biologically grounded, scalable tools for large-scale single-cell data analysis.

Enhancing TCR-Peptide Interaction Prediction with Pretrained Language Models and Molecular Representations

Understanding the binding specificity between T-cell receptors (TCRs) and peptide-major histocompatibility complexes (pMHCs) is central to immunotherapy and vaccine development. However, current predictive models struggle with generalization, especially in data-scarce settings and when faced with novel epitopes. We present LANTERN (Large lAnguage model-powered TCR-Enhanced Recognition Network), a deep learning framework that combines large-scale protein language models with chemical representations of peptides. By encoding TCR \b{eta}-chain sequences using ESM-1b and transforming peptide sequences into SMILES strings processed by MolFormer, LANTERN captures rich biological and chemical features critical for TCR-peptide recognition. Through extensive benchmarking against existing models such as ChemBERTa, TITAN, and NetTCR, LANTERN demonstrates superior performance, particularly in zero-shot and few-shot learning scenarios. Our model also benefits from a robust negative sampling strategy and shows significant clustering improvements via embedding analysis. These results highlight the potential of LANTERN to advance TCR-pMHC binding prediction and support the development of personalized immunotherapies.